HitPredict

Interactor 1: R144A (P50876)
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
Gene: RNF144A

Interactor 2: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	36758106
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IBR~UQ_con
Common GO terms	GO:0000151 - ubiquitin ligase complex GO:0000209 - protein polyubiquitination GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 292 Hs			1 147
+	Hs
		842095 R144A_HUMAN (1-292): 5.59e-97: 288: 100.00		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		919876 RN19A_HUMAN (16-276): 5.96e-75: 246: 25.00		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		919757 RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		895819 RN19B_HUMAN (13-276): 3.98e-73: 240: 25.54		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		312679 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20
+	Hs
		849498 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		312520 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		312553 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00
+	Hs
		895968 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		312528 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28
+	Hs
		849474 RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93		UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12
+	Hs
		1297383 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		312645 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73
+	Hs
		312639 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43
+	Mm
		854557 ARI2_MOUSE (2-231): 6.8e-64: 210: 25.96		UB2E3_MOUSE (4-146): 3.05e-74: 221: 66.43
+	Hs
		312522 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73
+	Mm
		854551 ARI2_MOUSE (2-231): 6.8e-64: 210: 25.96		UB2E1_MOUSE (4-146): 4.62e-73: 218: 65.73
+	Hs
		896576 ARI1_HUMAN (14-229): 1.58e-64: 213: 27.35		UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22
+	Hs
		312529 ARI2_HUMAN (2-231): 1.5e-64: 211: 25.53		UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22
+	Hs
		851901 RNF14_HUMAN (14-239): 1.82e-59: 198: 22.93		UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73