HitPredict

Interactor 1: RB27A (P51159)
Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram)
Gene: RAB27A

Interactor 2: RPH3L (Q9UNE2)
Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)
Gene: RPH3AL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	14593078, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0006887 - exocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 221 Hs			1 315
+	Rn
		222478 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RPH3L_RAT (1-300): 1.67e-104: 309: 78.67
+	Mm
		722683 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RPH3L_MOUSE (1-301): 1.24e-102: 304: 79.40
+	Mm
		1176143 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RPH3L_MOUSE (1-301): 1.24e-102: 304: 79.40
+	Hs
		845961 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		RP3A_HUMAN (1-313): 1.93e-83: 267: 35.33
+	Mm
		722679 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RP3A_MOUSE (1-297): 3.12e-82: 263: 36.96
+	Mm
		812778 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		RP3A_MOUSE (1-297): 3.12e-82: 263: 36.96
+	Rn
		812780 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RP3A_RAT (1-307): 3.11e-80: 258: 36.98
+	Ce
		104432 G5EBS5_CAEEL (4-213): 1.78e-87: 258: 59.05		RBF1_CAEEL (1-312): 9.51e-70: 236: 33.13
+	Hs
		845940 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL5_HUMAN (47-311): 5.46e-61: 208: 21.32
+	Mm
		1307888 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL3_MOUSE (45-309): 2.11e-61: 207: 19.15
+	Hs
		320135 RAB3D_HUMAN (2-221): 9.57e-86: 254: 38.64		SYTL4_HUMAN (47-313): 2.6e-57: 197: 18.38
+	Hs
		845942 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL4_HUMAN (47-313): 2.6e-57: 197: 18.38
+	Mm
		1193404 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		SYTL5_MOUSE (47-311): 9.47e-57: 197: 20.88
+	Hs
		845927 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		SYTL3_HUMAN (47-309): 2.21e-57: 196: 20.29
+	Rn
		926103 RAB3A_RAT (2-219): 1.05e-85: 254: 41.28		RIMS2_RAT (46-286): 1.45e-54: 193: 18.82
+	Mm
		722693 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS2_MOUSE (52-286): 1.39e-50: 181: 18.87
+	Mm
		1265039 RB27A_MOUSE (1-221): 1.14e-84: 252: 95.93		MELPH_MOUSE (47-312): 4.2e-51: 179: 16.91
+	Hs
		845948 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		MELPH_HUMAN (47-310): 2.08e-46: 167: 16.20
+	Mm
		722691 RAB3D_MOUSE (2-221): 3.88e-85: 253: 40.46		RIMS1_MOUSE (59-296): 5.68e-39: 148: 18.39
+	Hs
		845939 RB27A_HUMAN (1-221): 3.16e-85: 253: 100.00		MYRIP_HUMAN (47-167): 2.67e-31: 125: 25.20