HitPredict

Interactor 1: SCNNB (P51168)
Amiloride-sensitive sodium channel subunit beta (Beta-NaCH) (Epithelial Na(+) channel subunit beta) (Beta-ENaC) (ENaCB) (Nonvoltage-gated sodium channel 1 subunit beta) (SCNEB)
Gene: SCNN1B

Interactor 2: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	11244092
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 640 Hs			1 1606
+	Hs
		739596 SCNNA_HUMAN (21-627): 0: 558: 31.54		HECW1_HUMAN (1-1606): 0: 1184: 100.00
+	Hs
		845977 SCNNB_HUMAN (1-640): 0: 701: 100.00		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		808049 SCNNB_HUMAN (1-640): 0: 701: 100.00		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		739603 SCNNA_HUMAN (21-627): 0: 558: 31.54		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		808050 SCNNG_HUMAN (17-626): 0: 580: 36.22		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		739582 SCNNA_HUMAN (21-627): 0: 558: 31.54		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		125256 SCNNB_HUMAN (1-640): 0: 701: 100.00		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Rn
		739628 SCNNB_RAT (1-640): 0: 683: 83.44		NEDD4_RAT (754-1107): 2.07e-24: 113: 17.30
+	Hs
		845978 SCNNB_HUMAN (1-640): 0: 701: 100.00		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Mm
		808382 SCNNB_MOUSE (1-640): 0: 664: 83.91		NEDD4_MOUSE (754-1107): 6.29e-24: 111: 17.94
+	Mm
		1208291 SCNNB_MOUSE (1-640): 0: 664: 83.91		NED4L_MOUSE (686-1055): 9.1e-16: 85.6: 17.03
+	Mm
		93285 SCNNB_MOUSE (1-640): 0: 664: 83.91		E9PXB7_MOUSE (760-1062): 1.36e-13: 78.3: 17.82
+	Rn
		739631 SCNNG_RAT (16-625): 0: 586: 36.16		NEDD4_RAT (754-1107): 2.07e-24: 113: 17.30
+	Mm
		808383 SCNNG_MOUSE (16-625): 0: 587: 36.19		NEDD4_MOUSE (754-1107): 6.29e-24: 111: 17.94
+	Hs
		125257 SCNNG_HUMAN (17-626): 0: 580: 36.22		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Rn
		739630 SCNNG_RAT (16-625): 0: 586: 36.16		Q4V8H7_RAT (591-1050): 1.12e-18: 94.9: 16.77
+	Hs
		125197 SCNNA_HUMAN (21-627): 0: 558: 31.54		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Mm
		93286 SCNNG_MOUSE (16-625): 0: 587: 36.19		E9PXB7_MOUSE (760-1062): 1.36e-13: 78.3: 17.82
+	Hs
		845991 SCNNG_HUMAN (17-626): 0: 580: 36.22		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Hs
		739597 SCNNA_HUMAN (21-627): 0: 558: 31.54		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71