HitPredict

Interactor 1: RORG (P51449)
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Gene: RORC

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15604093
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 518 Hs			1 2063
+	Hs
		1057765 Q58EY0_HUMAN (22-509): 2.27e-123: 370: 45.10		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		265866 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		509950 VDR_HUMAN (11-509): 2.77e-74: 243: 18.04		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		740524 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		587169 RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		592827 NR1D1_HUMAN (1-488): 1.7e-105: 329: 28.71		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		130339 NR5A2_HUMAN (24-502): 7.37e-100: 313: 19.26		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		824479 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93
+	Hs
		265885 NR1I2_HUMAN (9-511): 2.29e-97: 303: 24.41		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		823750 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		SC24C_HUMAN (219-600): 6.59e-10: 66.7: 20.49
+	Hs
		824538 NR2C2_HUMAN (3-503): 1.71e-106: 331: 21.21		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47
+	Dm
		81155 ECR_DROME (11-513): 8.41e-95: 308: 22.75		LINT_DROME (274-1553): 7.56e-09: 63.5: 8.86
+	Hs
		509999 VDR_HUMAN (11-509): 2.77e-74: 243: 18.04		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		554279 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47
+	Hs
		740633 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		530817 RARG_HUMAN (6-105): 1.57e-45: 167: 50.50		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		587211 RXRA_HUMAN (3-169): 7.21e-45: 165: 30.73		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		818890 RXRG_HUMAN (19-127): 2.69e-44: 164: 44.04		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		740557 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Hs
		740556 PPARG_HUMAN (3-177): 8.61e-46: 169: 32.39		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23