HitPredict

Interactor 1: MECP2 (P51608)
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Gene: MECP2

Interactor 2: TBL1R (Q9BZK7)
F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)
Gene: TBL1XR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	28348241, 36890145, 23770565, 37822516
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 486 Hs			1 514
+	Mm
		1206590 MECP2_MOUSE (1-486): 5.34e-112: 341: 94.44		TBL1R_MOUSE (1-514): 2.98e-163: 474: 99.03
+	Hs
		245580 MECP2_HUMAN (1-486): 5.16e-113: 344: 100.00		TBL1X_HUMAN (1-514): 1.2e-150: 444: 86.34
+	Hs
		848145 MECP2_HUMAN (1-486): 5.16e-113: 344: 100.00		NLE1_HUMAN (23-293): 5.57e-36: 141: 13.61
+	Hs
		1281461 MBD1_HUMAN (95-220): 6.98e-31: 127: 31.78		FBXW7_HUMAN (39-423): 4.25e-69: 236: 15.64
+	Hs
		1264784 TITIN_HUMAN (240-472): 1.28e-12: 72.8: 19.57		SNR40_HUMAN (50-195): 7.63e-12: 68.7: 11.92