HitPredict

Interactor 1: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Interactor 2: ASXL2 (Q76L83)
Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2)
Gene: ASXL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26416890, 27705803, 32669118
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2035 Hs			1 1435
+	Hs
		152616 HCFC1_HUMAN (1-2035): 0: 643: 100.00		KMT2D_HUMAN (412-1023): 4.42e-14: 80: 13.50
+	Hs
		848287 HCFC1_HUMAN (1-2035): 0: 643: 100.00		ASXL3_HUMAN (72-1435): 5.5e-14: 79.7: 12.34
+	Hs
		848249 HCFC1_HUMAN (1-2035): 0: 643: 100.00		ASXL1_HUMAN (333-1435): 1.06e-13: 78.5: 12.31
+	Hs
		1231048 KLDC3_HUMAN (68-425): 9.22e-58: 207: 21.14		CRBG2_HUMAN (267-1124): 3.89e-25: 116: 11.90
+	Hs
		1057032 KLH20_HUMAN (2-263): 2.49e-55: 206: 14.39		MDC1_HUMAN (105-1326): 8.13e-25: 115: 9.03
+	Hs
		152704 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		KMT2D_HUMAN (412-1023): 4.42e-14: 80: 13.50
+	Dm
		113976 M9PB30_DROME (1365-2025): 2.64e-17: 91.4: 9.45		M9PB30_DROME (145-918): 2.71e-24: 113: 10.93