HitPredict

Interactor 1: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Interactor 2: THAP1 (Q9NVV9)
THAP domain-containing protein 1
Gene: THAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.637

Property	Details
Experiments	20200153, 28486698
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0007049 - cell cycle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2035 Hs			1 213
+	Hs
		848289 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP2_HUMAN (1-176): 1.16e-53: 173: 34.44
+	Hs
		848260 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP6_HUMAN (1-179): 3.31e-49: 161: 24.61
+	Hs
		848262 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP3_HUMAN (1-181): 3.67e-48: 159: 29.46
+	Hs
		848280 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THAP7_HUMAN (1-133): 3.82e-32: 119: 26.67
+	Hs
		848270 HCFC1_HUMAN (1-2035): 0: 643: 100.00		THA11_HUMAN (1-90): 2.95e-22: 93.8: 27.55
+	Hs
		1328335 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		THAP2_HUMAN (1-176): 1.16e-53: 173: 34.44
+	Hs
		1259626 HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51		THAP3_HUMAN (1-181): 3.67e-48: 159: 29.46
+	Dm
		1359883 HCF_DROME (948-2031): 9.87e-34: 144: 15.87		MBDR2_DROME (1-146): 1.56e-25: 105: 18.54