HitPredict

Interactor 1: IRAK1 (P51617)
Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)
Gene: IRAK1

Interactor 2: IRAK3 (Q9Y616)
Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)
Gene: IRAK3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.904

The method score is based on:

Property Details
Experiments 21903422, 12138165, 19166926, 10383454
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, in-gel kinase assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death, Pkinase~Pkinase
Common GO terms GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 12 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 712
Hs

1 596
+ Mm
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+ At
+ At
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024