HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: RNF10 (Q8N5U6)
E3 ubiquitin-protein ligase RNF10 (EC 2.3.2.27) (RING finger protein 10)
Gene: RNF10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	33961781, 19549727
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 811
+	Hs
		1235248 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF10_HUMAN (1-811): 0: 1013: 100.00
+	Hs
		919785 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF10_HUMAN (1-811): 0: 1013: 100.00
+	Hs
		895845 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RNF10_HUMAN (1-811): 0: 1013: 100.00
+	Sc
		549836 UBC4_YEAST (3-147): 3.9e-79: 232: 79.31		MAG2_YEAST (3-695): 6.81e-156: 472: 20.19
+	Hs
		749252 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17
+	Hs
		749339 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17
+	Hs
		749301 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		BRCA1_HUMAN (207-497): 4.44e-45: 177: 17.17
+	Dm
		639398 UBCD1_DROME (1-147): 1.87e-81: 238: 89.12		Q8IR26_DROME (194-307): 2.55e-39: 149: 26.09
+	Dm
		639411 UBCD1_DROME (1-147): 1.87e-81: 238: 89.12		Q9VXP1_DROME (194-307): 4.34e-39: 148: 26.09
+	Hs
		1307272 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RNF5_HUMAN (210-317): 3.13e-36: 136: 20.37
+	Hs
		1292368 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		RN185_HUMAN (215-309): 3.43e-35: 134: 21.05
+	Hs
		849424 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RNF5_HUMAN (210-317): 3.13e-36: 136: 20.37
+	Hs
		919838 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RNF5_HUMAN (210-317): 3.13e-36: 136: 20.37
+	At
		715141 UBC9_ARATH (1-147): 8.78e-82: 238: 77.55		Q9LN67_ARATH (223-318): 2.79e-35: 135: 21.43
+	Hs
		849409 UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00		RN185_HUMAN (215-309): 3.43e-35: 134: 21.05
+	Hs
		895892 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RNF5_HUMAN (210-317): 3.13e-36: 136: 20.37
+	Hs
		919826 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		RN185_HUMAN (215-309): 3.43e-35: 134: 21.05
+	Hs
		895880 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		RN185_HUMAN (215-309): 3.43e-35: 134: 21.05
+	Sc
		549817 UBC4_YEAST (3-147): 3.9e-79: 232: 79.31		SLX8_YEAST (147-281): 3.94e-25: 107: 19.71
+	Sc
		549834 UBC4_YEAST (3-147): 3.9e-79: 232: 79.31		PEX10_YEAST (171-278): 1.49e-14: 77.8: 18.18