HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: OTUB1 (Q96FW1)
Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)
Gene: OTUB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.975

Property	Details
Experiments	32296183, 32049508, 33961781, 26752685, 35927303, 22124327, 24071738, 24403071, unassigned1304, 19549727, unassigned1260
Identification Methods	two hybrid, pull down, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Peptidase_C65~UQ_con
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 271
+	Hs
		1291615 UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		919824 UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		895878 UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		1291545 UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		1282326 UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		851868 UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Hs
		896520 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		OTUB1_HUMAN (1-271): 3.25e-150: 422: 100.00
+	Mm
		896585 UBE2N_MOUSE (4-147): 1.92e-68: 205: 45.83		OTUB1_MOUSE (1-271): 3.18e-150: 422: 99.63
+	Ce
		715115 UBC2_CAEEL (1-147): 7.45e-82: 239: 89.12		OTUBL_CAEEL (3-271): 2.76e-122: 352: 34.42
+	Hs
		896513 UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83		OTUB2_HUMAN (47-270): 1.25e-104: 305: 47.77