HitPredict

Interactor 1: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Interactor 2: CCL18 (P55774)
C-C motif chemokine 18 (Alternative macrophage activation-associated CC chemokine 1) (AMAC-1) (CC chemokine PARC) (Dendritic cell chemokine 1) (DC-CK1) (Macrophage inflammatory protein 4) (MIP-4) (Pulmonary and activation-regulated chemokine) (Small-inducible cytokine A18) [Cleaved into: CCL18(1-68); CCL18(3-69); CCL18(4-69)]
Gene: CCL18

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10640766
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0006955 - immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 355 Hs			1 89
+	Hs
		561728 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CL3L1_HUMAN (1-89): 2.5e-34: 114: 59.14
+	Hs
		486230 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL3_HUMAN (1-89): 8.49e-34: 113: 60.87
+	Mm
		500591 CCR3_MOUSE (9-355): 3.86e-90: 276: 70.03		CCL3_MOUSE (1-89): 4.16e-32: 108: 53.76
+	Hs
		526560 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL4_HUMAN (1-88): 1.39e-32: 109: 42.39
+	Hs
		686667 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL14_HUMAN (1-88): 2.5e-31: 106: 41.94
+	Hs
		849723 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL18_HUMAN (1-89): 5.19e-32: 108: 100.00
+	Mm
		534669 CCR3_MOUSE (9-355): 3.86e-90: 276: 70.03		CCL4_MOUSE (1-88): 1.96e-27: 96.9: 45.65
+	Hs
		686635 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL8_HUMAN (1-87): 1.58e-28: 99: 31.52
+	Hs
		686626 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL23_HUMAN (1-89): 7.23e-28: 98.8: 36.28
+	Hs
		686668 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL15_HUMAN (1-86): 1.12e-27: 98.4: 36.70
+	Hs
		528244 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL5_HUMAN (1-88): 1.85e-26: 94.6: 38.46
+	Hs
		686636 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL7_HUMAN (1-89): 4.28e-26: 93.8: 31.92
+	Hs
		528201 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL2_HUMAN (1-89): 5.39e-26: 93.4: 30.85
+	Hs
		607526 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL1_HUMAN (1-87): 6.88e-24: 88: 26.67
+	Mm
		486212 CCR8_MOUSE (1-335): 1.93e-91: 279: 37.57		CCL1_MOUSE (1-86): 1.72e-21: 81.9: 30.00
+	Hs
		180158 CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54		CCL16_HUMAN (1-87): 2.93e-22: 85: 34.04
+	Hs
		849725 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL17_HUMAN (1-86): 1.13e-24: 90: 30.23
+	Hs
		607528 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL1_HUMAN (1-87): 6.88e-24: 88: 26.67
+	Hs
		180162 CCR8_HUMAN (1-338): 1.38e-86: 267: 38.60		CCL16_HUMAN (1-87): 2.93e-22: 85: 34.04
+	Hs
		134312 ACKR4_HUMAN (10-343): 1e-85: 264: 30.09		CCL21_HUMAN (27-88): 9.65e-18: 73.8: 33.33