HitPredict

Interactor 1: NEK2 (P51955)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
Gene: NEK2

Interactor 2: MYOME (Q5VU43)
Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)
Gene: PDE4DIP

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	21900206
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005813 - centrosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 2346
+	Rn
		871343 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		MYOME_RAT (1-2346): 0: 644: 77.09
+	Hs
		851352 NEK2_HUMAN (1-445): 5.46e-146: 425: 100.00		CP250_HUMAN (682-2334): 3.75e-54: 212: 9.73
+	Hs
		1313528 SIK2_HUMAN (2-396): 3.05e-111: 350: 25.47		CP250_HUMAN (682-2334): 3.75e-54: 212: 9.73
+	Hs
		724726 NEK2_HUMAN (1-445): 5.46e-146: 425: 100.00		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Hs
		1023137 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH2_HUMAN (1264-2333): 5.78e-32: 139: 10.08
+	Hs
		725242 SIK2_HUMAN (2-396): 3.05e-111: 350: 25.47		MYH10_HUMAN (1099-2077): 1.03e-18: 96.2: 11.20
+	Rn
		871335 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		MYH10_RAT (1529-2333): 3.93e-23: 110: 12.30
+	Hs
		522609 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH7_HUMAN (1-709): 1.93e-23: 111: 10.58
+	Hs
		528369 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH6_HUMAN (1376-2333): 1.06e-22: 109: 8.98
+	Hs
		725223 MARK4_HUMAN (5-324): 3.04e-109: 341: 28.04		MYH10_HUMAN (1099-2077): 1.03e-18: 96.2: 11.20
+	Hs
		728513 SIK2_HUMAN (2-396): 3.05e-111: 350: 25.47		MYH11_HUMAN (31-473): 4.26e-15: 84.3: 11.74
+	Hs
		522545 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH1_HUMAN (1591-2329): 2.23e-20: 101: 10.95
+	Hs
		725010 SIK2_HUMAN (2-396): 3.05e-111: 350: 25.47		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Rn
		102485 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		G3V6P7_RAT (789-1593): 1.75e-15: 85.4: 13.77
+	Hs
		724967 MARK4_HUMAN (5-324): 3.04e-109: 341: 28.04		MYH9_HUMAN (1753-2327): 1.1e-12: 76.2: 11.23
+	Hs
		528408 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH8_HUMAN (1820-2316): 2.84e-12: 75: 11.75
+	Rn
		871291 AAPK1_RAT (4-383): 1.2e-108: 333: 27.32		MYH9_RAT (1753-2310): 2.74e-11: 71.6: 10.68
+	Hs
		1023100 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		AKAP9_HUMAN (196-822): 2.21e-10: 68.9: 11.25
+	Hs
		1023138 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH13_HUMAN (1243-2074): 3.08e-10: 68.1: 11.50
+	Hs
		502911 STK4_HUMAN (6-442): 1.98e-108: 330: 22.75		MYH3_HUMAN (1-361): 4.36e-09: 64.2: 10.90