HitPredict

Interactor 1: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	19961560
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~Ras, Arm_3~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 529 Hs			1 192
+	Hs
		853220 IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		134868 IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		238654 IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		853562 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		545276 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		853554 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		853556 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436216 IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45