HitPredict

Interactor 1: IMA (P52295)
Importin subunit alpha (Karyopherin subunit alpha) (Pendulin)
Gene: Pen

Interactor 2: NUP50 (Q7K0D8)
Nuclear pore complex protein Nup50 (50 kDa nucleoporin)
Gene: NUP50

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.80	0.749

Property	Details
Experiments	14605208, 37061542, 22036573
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~NUP50, Arm_3~NUP50
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 522 Dm			1 564
+	Hs
		134978 IMA3_HUMAN (6-522): 1.08e-144: 427: 45.84		NUP50_HUMAN (3-563): 2.7e-91: 290: 26.41
+	Hs
		131527 IMA4_HUMAN (2-522): 1.47e-141: 419: 44.53		NUP50_HUMAN (3-563): 2.7e-91: 290: 26.41
+	Hs
		853515 IMA1_HUMAN (8-522): 3.38e-139: 414: 49.04		NUP50_HUMAN (3-563): 2.7e-91: 290: 26.41
+	Hs
		1192291 Q7Z726_HUMAN (8-522): 3.65e-139: 413: 49.04		NUP50_HUMAN (3-563): 2.7e-91: 290: 26.41
+	Hs
		238747 IMA7_HUMAN (2-521): 2.91e-134: 401: 46.53		NUP50_HUMAN (3-563): 2.7e-91: 290: 26.41
+	Hs
		134921 IMA3_HUMAN (6-522): 1.08e-144: 427: 45.84		RGPD4_HUMAN (36-563): 2.23e-64: 230: 12.07
+	Hs
		63862 IMA3_HUMAN (6-522): 1.08e-144: 427: 45.84		RGPD3_HUMAN (36-563): 1.88e-61: 222: 11.49
+	Hs
		152769 IMA1_HUMAN (8-522): 3.38e-139: 414: 49.04		RGPD8_HUMAN (36-563): 1.57e-63: 228: 11.32
+	Hs
		853440 IMA1_HUMAN (8-522): 3.38e-139: 414: 49.04		RGPD5_HUMAN (36-563): 1.13e-63: 228: 11.66
+	Hs
		134964 IMA3_HUMAN (6-522): 1.08e-144: 427: 45.84		RANB3_HUMAN (154-557): 1.47e-49: 181: 10.31
+	Hs
		134843 IMA3_HUMAN (6-522): 1.08e-144: 427: 45.84		RANG_HUMAN (415-564): 6.32e-45: 159: 16.46
+	Hs
		131396 IMA4_HUMAN (2-522): 1.47e-141: 419: 44.53		RANG_HUMAN (415-564): 6.32e-45: 159: 16.46
+	At
		1280910 IMPA1_ARATH (2-522): 3.41e-152: 447: 43.21		NU50A_ARATH (316-563): 5.16e-28: 118: 15.60
+	At
		1320502 IMPA6_ARATH (2-522): 1.95e-148: 438: 42.16		NU50A_ARATH (316-563): 5.16e-28: 118: 15.60
+	At
		97810 IMPA2_ARATH (2-522): 5.06e-148: 436: 43.26		NU50A_ARATH (316-563): 5.16e-28: 118: 15.60
+	At
		285384 IMPA4_ARATH (2-522): 1.99e-145: 430: 42.83		NU50A_ARATH (316-563): 5.16e-28: 118: 15.60
+	At
		138100 IMPA3_ARATH (2-522): 1.19e-143: 425: 41.17		NU50A_ARATH (316-563): 5.16e-28: 118: 15.60
+	Hs
		134854 IMA3_HUMAN (6-522): 1.08e-144: 427: 45.84		RBP2_HUMAN (34-431): 1.71e-12: 73: 12.33
+	Hs
		131404 IMA4_HUMAN (2-522): 1.47e-141: 419: 44.53		RBP2_HUMAN (34-431): 1.71e-12: 73: 12.33
+	Hs
		834693 IMA1_HUMAN (8-522): 3.38e-139: 414: 49.04		RBP2_HUMAN (34-431): 1.71e-12: 73: 12.33