Protein: MK08
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)

Gene: MK08, MAPK8
Organism: Homo sapiens
Interactions: 245
UniProt ID: P45983

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0004705 - JUN kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853616

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

14

20

Small-scale

0.985

High

161960

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

9

20

Small-scale

0.979

High

853733

DUS16
Dual specificity protein phosphatase 16

7

20

Small-scale

0.961

High

853672

DUS8
Dual specificity protein phosphatase 8

6

20

High-throughput

0.950

High

853615

MK09
Mitogen-activated protein kinase 9

6

18

Small-scale

0.949

High

853763

DUS10
Dual specificity protein phosphatase 10

5

20

Small-scale

0.932

High

853673

M3K1
Mitogen-activated protein kinase kinase kinase 1

5

20

Small-scale

0.928

High

853669

DUS4
Dual specificity protein phosphatase 4

4

20

Small-scale

0.878

High

362940

EGFR
Epidermal growth factor receptor

3

14

High-throughput

0.858

High

853614

MK08
Mitogen-activated protein kinase 8

3

17

Small-scale

0.834

High

658576

KS6B1
Ribosomal protein S6 kinase beta-1

2

20

Small-scale

0.826

High

772471

IRS1
Insulin receptor substrate 1

2

10

Small-scale

0.807

High

651212

CBL
E3 ubiquitin-protein ligase CBL

2

8

Small-scale

0.806

High

703915

DUS1
Dual specificity protein phosphatase 1

2

20

Small-scale

0.800

High

429477

JUN
Transcription factor Jun

83

20

Small-scale

0.773

High

464868

SP1
Transcription factor Sp1

2

11

Small-scale

0.768

High

807977

CDN1A
Cyclin-dependent kinase inhibitor 1

2

15

Small-scale

0.768

High

853762

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

15

Small-scale

0.768

High

583492

ATF2
Cyclic AMP-dependent transcription factor ATF-2

16

20

Small-scale

0.763

High

853729

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

20

Small-scale

0.756

High

177183

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

2

5

High-throughput

0.754

High

853757

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

10

9

Small-scale

0.754

High

214551

WDR62
WD repeat-containing protein 62

7

16

Small-scale

0.752

High

413367

P53
Cellular tumor antigen p53

9

12

Small-scale

0.750

High

213855

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

17

Small-scale

0.747

High

853619

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

15

Small-scale

0.724

High

479777

GSTP1
Glutathione S-transferase P

4

8

Small-scale

0.702

High

622420

ELK1
ETS domain-containing protein Elk-1

4

20

Small-scale

0.701

High

400450

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.698

High

853740

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

20

High-throughput

0.698

High

158412

RFXK
DNA-binding protein RFXANK

1

8

High-throughput

0.691

High

247249

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

8

High-throughput

0.691

High

585771

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

15

High-throughput

0.691

High

625236

CSK22
Casein kinase II subunit alpha'

1

19

High-throughput

0.691

High

853631

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

853707

VRK2
Serine/threonine-protein kinase VRK2

1

20

Small-scale

0.691

High

853732

CDK19
Cyclin-dependent kinase 19

1

20

High-throughput

0.691

High

591520

H2AX
Histone H2AX

4

6

Small-scale

0.689

High

853755

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

20

Small-scale

0.676

High

216303

KCAB3
Voltage-gated potassium channel subunit beta-3

3

3

High-throughput

0.667

High

827694

STAT3
Signal transducer and activator of transcription 3

3

8

Small-scale

0.660

High

853678

BMPR2
Bone morphogenetic protein receptor type-2

1

10

High-throughput

0.656

High

853728

RBM15
RNA-binding protein 15

1

9

High-throughput

0.656

High

853746

ZN219
Zinc finger protein 219

1

1

High-throughput

0.656

High

193527

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

18

Small-scale

0.647

High

728095

AKT1
RAC-alpha serine/threonine-protein kinase

1

20

Small-scale

0.647

High

842942

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

15

Small-scale

0.647

High

332288

ATE1
Arginyl-tRNA--protein transferase 1

3

0

High-throughput

0.638

High

421681

A4
Amyloid-beta precursor protein

2

8

Small-scale

0.635

High

853743

WWOX
WW domain-containing oxidoreductase

2

3

Small-scale

0.631

High

853725

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

3

Small-scale

0.629

High

712152

TKT
Transketolase

2

3

High-throughput

0.628

High

853617

CRK
Adapter molecule crk

2

4

Small-scale

0.624

High

853649

HSF1
Heat shock factor protein 1

2

8

Small-scale

0.624

High

586245

ZEP1
Zinc finger protein 40

1

3

High-throughput

0.621

High

853756

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

8

High-throughput

0.618

High

241007

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

374454

RASH
GTPase HRas

1

9

Small-scale

0.618

High

461253

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

728560

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.618

High

853626

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

18

Small-scale

0.618

High

853657

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.618

High

853685

KPCD1
Serine/threonine-protein kinase D1

1

20

Small-scale

0.618

High

853688

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

12

Small-scale

0.618

High

853690

MK14
Mitogen-activated protein kinase 14

1

17

Small-scale

0.618

High

853760

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

20

Small-scale

0.618

High

853689

NF2L2
Nuclear factor erythroid 2-related factor 2

2

20

Small-scale

0.611

High

327564

ELP1
Elongator complex protein 1

1

1

Small-scale

0.607

High

791161

SYUA
Alpha-synuclein

2

5

Small-scale

0.606

High

529291

TAU
Microtubule-associated protein tau

2

19

Small-scale

0.602

High

652470

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

18

Small-scale

0.602

High

853684

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

13

Small-scale

0.602

High

853758

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.602

High

764520

CTNB1
Catenin beta-1

1

11

Small-scale

0.597

High

605058

JUND
Transcription factor JunD

2

20

Small-scale

0.595

High

853710

RPTOR
Regulatory-associated protein of mTOR

2

8

Small-scale

0.594

High

853705

ZN605
Zinc finger protein 605

1

0

High-throughput

0.589

High

699640

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

3

Small-scale

0.588

High

853680

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.586

High

853693

NFE2
Transcription factor NF-E2 45 kDa subunit

1

20

Small-scale

0.586

High

842681

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

19

Small-scale

0.586

High

853661

B2CL1
Bcl-2-like protein 1

2

13

Small-scale

0.585

High

371410

MYC
Myc proto-oncogene protein

1

8

Small-scale

0.578

High

713340

SPB3
Serpin B3

1

3

Small-scale

0.578

High

853621

SPB4
Serpin B4

1

3

Small-scale

0.578

High

853624

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

Small-scale

0.578

High

853717

GEMI5
Gem-associated protein 5

1

7

Small-scale

0.578

High

853730

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

2

Small-scale

0.578

High

116938

J3KNB8
Mitogen-activated protein kinase kinase kinase 4

1

20

High-throughput

0.575

High

231549

PRKY
Putative serine/threonine-protein kinase PRKY

1

12

High-throughput

0.575

High

254872

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.575

High

295567

CIB2
Calcium and integrin-binding family member 2

1

1

High-throughput

0.575

High

722865

SSR2
Somatostatin receptor type 2

1

7

High-throughput

0.575

High

853635

MK10
Mitogen-activated protein kinase 10

1

18

High-throughput

0.575

High

853642

CDC42
Cell division control protein 42 homolog

1

7

Small-scale

0.575

High

853643

RHOA
Transforming protein RhoA

1

7

Small-scale

0.575

High

853644

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

Small-scale

0.575

High

853670

FADD
FAS-associated death domain protein

1

6

Small-scale

0.575

High

853683

CASP8
Caspase-8

1

11

Small-scale

0.575

High

853691

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

16

Small-scale

0.575

High

853720

CASPA
Caspase-10

1

11

Small-scale

0.575

High

297773

PIAS2
E3 SUMO-protein ligase PIAS2

1

1

Small-scale

0.573

High

853679

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

5

High-throughput

0.571

High

853759

RUVB1
RuvB-like 1

2

5

High-throughput

0.571

High

853622

PAXI
Paxillin

1

9

Small-scale

0.561

High

853721

APBB2
Amyloid beta precursor protein binding family B member 2

1

2

Small-scale

0.561

High

853724

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.561

High

853752

HDAC9
Histone deacetylase 9

1

12

Small-scale

0.561

High

853754

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.561

High

853656

REL
Proto-oncogene c-Rel

1

11

Small-scale

0.552

High

219612

B2L11
Bcl-2-like protein 11

1

3

Small-scale

0.550

High

522058

BCL2
Apoptosis regulator Bcl-2

1

13

Small-scale

0.550

High

702323

ELK4
ETS domain-containing protein Elk-4

1

20

Small-scale

0.550

High

853651

SPIB
Transcription factor Spi-B

1

9

Small-scale

0.550

High

853666

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

1

Small-scale

0.550

High

239413

3BP5
SH3 domain-binding protein 5

1

2

Small-scale

0.549

High

428318

RLA2
Large ribosomal subunit protein P2

1

3

High-throughput

0.541

High

834272

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.541

High

209213

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.536

High

610563

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.536

High

636829

GSTM3
Glutathione S-transferase Mu 3

1

8

High-throughput

0.536

High

821248

TCPZ
T-complex protein 1 subunit zeta

1

14

High-throughput

0.536

High

853623

TCPG
T-complex protein 1 subunit gamma

1

15

High-throughput

0.536

High

853628

TCPQ
T-complex protein 1 subunit theta

1

19

High-throughput

0.536

High

853629

TCPD
T-complex protein 1 subunit delta

1

12

High-throughput

0.536

High

853633

NUP98
Nuclear pore complex protein Nup98-Nup96

1

5

High-throughput

0.536

High

853634

CATC
Dipeptidyl peptidase 1

1

2

High-throughput

0.536

High

853646

TCPB
T-complex protein 1 subunit beta

1

16

High-throughput

0.536

High

853650

MYT1
Myelin transcription factor 1

1

3

Small-scale

0.536

High

853671

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.536

High

853686

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

853699

RM02
Large ribosomal subunit protein uL2m

1

1

High-throughput

0.536

High

853703

CRTC3
CREB-regulated transcription coactivator 3

1

3

High-throughput

0.536

High

853711

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

6

High-throughput

0.536

High

853713

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.536

High

853714

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

4

High-throughput

0.536

High

853723

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

853747

ZO2
Tight junction protein 2

1

10

High-throughput

0.536

High

783528

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

20

Small-scale

0.527

High

853654

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

Small-scale

0.527

High

853726

BMF
Bcl-2-modifying factor

1

0

Small-scale

0.527

High

853625

CAMP
Cathelicidin antimicrobial peptide

1

0

High-throughput

0.518

High

853630

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.518

High

853652

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.518

High

853658

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

High-throughput

0.518

High

278033

FLNB
Filamin-B

1

13

Small-scale

0.515

High

302699

SYUG
Gamma-synuclein

1

5

Small-scale

0.515

High

853677

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.513

High

853696

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

0

High-throughput

0.513

High

853702

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

853734

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

853736

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

High-throughput

0.513

High

853737

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

853744

JKAMP
JNK1/MAPK8-associated membrane protein

1

1

Small-scale

0.512

High

536693

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.508

High

853641

SCND1
SCAN domain-containing protein 1

1

2

High-throughput

0.508

High

853745

DAPLE
Protein Daple

1

13

High-throughput

0.508

High

388050

MBP
Myelin basic protein

1

9

Small-scale

0.501

High

609912

SPI1
Transcription factor PU.1

1

11

Small-scale

0.501

High

840016

CASP3
Caspase-3

1

11

Small-scale

0.501

High

853627

ETV1
ETS translocation variant 1

1

20

Small-scale

0.501

High

853645

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.501

High

853647

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.501

High

853655

PAX2
Paired box protein Pax-2

1

5

Small-scale

0.501

High

853659

APLP2
Amyloid beta precursor like protein 2

1

8

Small-scale

0.501

High

853663

EP300
Histone acetyltransferase p300

1

15

Small-scale

0.501

High

853665

TFCP2
Alpha-globin transcription factor CP2

1

2

Small-scale

0.501

High

853674

ATM
Serine-protein kinase ATM

1

6

Small-scale

0.501

High

853706

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

3

Small-scale

0.501

High

853761

NCOA3
Nuclear receptor coactivator 3

1

6

Small-scale

0.501

High

853681

GANAB
Neutral alpha-glucosidase AB

1

5

High-throughput

0.494

High

505087

BNIP5
Protein BNIP5

1

2

High-throughput

0.489

High

853697

RABL3
Rab-like protein 3

1

6

High-throughput

0.489

High

853698

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

5

High-throughput

0.489

High

853715

F110D
Protein FAM110D

1

1

High-throughput

0.489

High

853738

WDCP
WD repeat and coiled-coil-containing protein

1

1

High-throughput

0.489

High

853751

CC018
Uncharacterized protein C3orf18

1

1

High-throughput

0.489

High

853664

PNRC1
Proline-rich nuclear receptor coactivator 1

1

0

High-throughput

0.486

High

853727

F193B
Protein FAM193B

1

0

High-throughput

0.486

High

853653

ID2
DNA-binding protein inhibitor ID-2

1

4

High-throughput

0.481

High

853668

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

12

Small-scale

0.481

High

853741

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.481

High

853742

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.480

High

127018

APBB1
Amyloid beta precursor protein binding family B member 1

1

2

Small-scale

0.479

High

208976

CYB5B
Cytochrome b5 type B

1

4

High-throughput

0.479

High

243906

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

20

Small-scale

0.479

High

403903

GCR
Glucocorticoid receptor

1

17

Small-scale

0.479

High

437117

K2C8
Keratin, type II cytoskeletal 8

1

3

Small-scale

0.479

High

442633

RB
Retinoblastoma-associated protein

1

9

Small-scale

0.479

High

446385

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.479

High

603624

JUNB
Transcription factor JunB

1

20

Small-scale

0.479

High

605243

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

20

Small-scale

0.479

High

627934

ANXA7
Annexin A7

1

4

High-throughput

0.479

High

697032

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

Small-scale

0.479

High

729666

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

839196

MTOR
Serine/threonine-protein kinase mTOR

1

9

Small-scale

0.479

High

853618

CRKL
Crk-like protein

1

4

Small-scale

0.479

High

853636

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

Small-scale

0.479

High

853638

CTBP2
C-terminal-binding protein 2

1

4

High-throughput

0.479

High

853640

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

Small-scale

0.479

High

853660

BAX
Apoptosis regulator BAX

1

13

Small-scale

0.479

High

853667

TRAF2
TNF receptor-associated factor 2

1

4

Small-scale

0.479

High

853675

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

11

Small-scale

0.479

High

853676

HDAC1
Histone deacetylase 1

1

7

Small-scale

0.479

High

853687

SF01
Splicing factor 1

1

1

High-throughput

0.479

High

853692

BAK
Bcl-2 homologous antagonist/killer

1

13

Small-scale

0.479

High

853700

H2A2A
Histone H2A type 2-A

1

5

High-throughput

0.479

High

853712

BANP
Protein BANP

1

1

Small-scale

0.479

High

853718

STAB2
Stabilin-2

1

7

Small-scale

0.479

High

853731

TBB2B
Tubulin beta-2B chain

1

9

High-throughput

0.479

High

853749

RLP24
Probable ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

853750

SCOC
Short coiled-coil protein

1

0

High-throughput

0.460

High

853709

CCD50
Coiled-coil domain-containing protein 50

1

0

Small-scale

0.458

High

853739

GORS2
Golgi reassembly-stacking protein 2

1

5

Small-scale

0.457

High

163257

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

7

Small-scale

0.445

High

246220

MABP1
Mitogen-activated protein kinase-binding protein 1

1

16

High-throughput

0.445

High

582702

EZRI
Ezrin

1

12

Small-scale

0.445

High

622549

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

7

Small-scale

0.445

High

674962

TNR6
Tumor necrosis factor receptor superfamily member 6

1

7

Small-scale

0.445

High

683794

MOES
Moesin

1

12

Small-scale

0.445

High

833896

HNF4A
Hepatocyte nuclear factor 4-alpha

1

12

Small-scale

0.445

High

853632

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.445

High

853662

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

13

Small-scale

0.445

High

853694

H2A2C
Histone H2A type 2-C

1

5

High-throughput

0.445

High

853735

CEP44
Centrosomal protein of 44 kDa

1

1

High-throughput

0.445

High

597863

LYAM2
E-selectin

1

2

Small-scale

0.437

High

853716

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

8

Small-scale

0.437

High

853719

TM9S4
Transmembrane 9 superfamily member 4

1

1

High-throughput

0.437

High

853620

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.426

High

853637

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.426

High

76391

B4DT77
Annexin

1

4

High-throughput

0.407

High

409304

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

4

High-throughput

0.407

High

628394

KLK2
Kallikrein-2

1

2

High-throughput

0.407

High

853695

SMTL2
Smoothelin-like protein 2

1

11

High-throughput

0.407

High

853708

SYT12
Synaptotagmin-12

1

5

High-throughput

0.407

High

853722

EMID1
EMI domain-containing protein 1

1

2

High-throughput

0.407

High

853704

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.282

High

853648

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

853682

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

853701

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low

853748

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

853639

CLD6
Claudin-6

1

0

Small-scale

0.257

Low

853753

VANG2
Vang-like protein 2

1

0

Small-scale

0.249

Low

116488

H7C0N4
Splicing factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025