HitPredict

Interactor 1: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	20709748, 28514442, 11948427, 31980649, 33961781, 35271311, 20936779, 25150978, unassigned2173
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 192
+	Hs
		545277 GDS1_HUMAN (1-607): 0: 917: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		854080 GDS1_HUMAN (1-607): 0: 917: 100.00		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		854093 GDS1_HUMAN (1-607): 0: 917: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		854081 GDS1_HUMAN (1-607): 0: 917: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		854084 GDS1_HUMAN (1-607): 0: 917: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436217 GDS1_HUMAN (1-607): 0: 917: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45