HitPredict

Interactor 1: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Interactor 2: DIRA2 (Q96HU8)
GTP-binding protein Di-Ras2 (Distinct subgroup of the Ras family member 2)
Gene: DIRAS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.80	0.806

Property	Details
Experiments	32296183, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 199
+	Hs
		303756 GDS1_HUMAN (1-607): 0: 917: 100.00		DIRA1_HUMAN (1-199): 2.07e-101: 292: 78.89
+	Hs
		854133 GDS1_HUMAN (1-607): 0: 917: 100.00		RAB1B_HUMAN (2-196): 2.25e-81: 241: 29.85
+	Hs
		318087 GDS1_HUMAN (1-607): 0: 917: 100.00		DIRA3_HUMAN (7-199): 9.58e-53: 170: 48.97
+	Hs
		854082 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1B_HUMAN (7-185): 3.46e-46: 152: 43.89
+	Hs
		854088 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1A_HUMAN (7-173): 2.58e-46: 152: 45.83
+	Hs
		854154 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2C_HUMAN (7-166): 3.73e-42: 141: 51.88
+	Hs
		854083 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2B_HUMAN (7-166): 2.37e-40: 137: 49.38
+	Hs
		854120 GDS1_HUMAN (1-607): 0: 917: 100.00		RHES_HUMAN (6-170): 1.05e-38: 135: 43.10
+	Hs
		486015 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP2A_HUMAN (7-166): 2.45e-37: 129: 51.25
+	Dm
		51787 GDS1_DROME (62-536): 0: 540: 31.27		O96692_DROME (20-166): 3.19e-37: 129: 44.22
+	Dm
		51789 GDS1_DROME (62-536): 0: 540: 31.27		RALA_DROME (8-193): 4.07e-34: 121: 36.90
+	Dm
		51795 GDS1_DROME (62-536): 0: 540: 31.27		Q962I2_DROME (8-182): 3.15e-33: 119: 38.29