HitPredict

Interactor 1: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Interactor 2: KBRS2 (Q9NYR9)
NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)
Gene: NKIRAS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 607 Hs			1 191
+	Hs
		854082 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1B_HUMAN (3-189): 1.31e-82: 244: 26.60
+	Hs
		854088 GDS1_HUMAN (1-607): 0: 917: 100.00		RAP1A_HUMAN (3-171): 6.1e-80: 237: 26.47
+	Hs
		349206 GDS1_HUMAN (1-607): 0: 917: 100.00		RASH_HUMAN (17-190): 5.34e-75: 225: 25.29
+	Hs
		854133 GDS1_HUMAN (1-607): 0: 917: 100.00		RAB1B_HUMAN (5-184): 4.89e-71: 215: 21.67
+	Hs
		506444 GDS1_HUMAN (1-607): 0: 917: 100.00		RALB_HUMAN (6-168): 1.09e-11: 62.8: 29.27
+	Hs
		488066 GDS1_HUMAN (1-607): 0: 917: 100.00		RRAS_HUMAN (33-187): 4.19e-11: 61.2: 27.85
+	Hs
		854120 GDS1_HUMAN (1-607): 0: 917: 100.00		RHES_HUMAN (4-175): 7.37e-11: 61.2: 30.69
+	Xl
		292764 GDS1A_XENLA (1-607): 0: 899: 85.50		RALBB_XENLA (6-161): 8.82e-12: 63.2: 29.94
+	Xl
		292765 GDS1A_XENLA (1-607): 0: 899: 85.50		RALBA_XENLA (6-168): 1.02e-11: 62.8: 28.66
+	Dm
		51789 GDS1_DROME (62-536): 0: 540: 31.27		RALA_DROME (6-187): 2.83e-80: 238: 26.37
+	Dm
		51795 GDS1_DROME (62-536): 0: 540: 31.27		Q962I2_DROME (6-187): 2.12e-78: 233: 25.82