Protein: KS6A6
Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)

Gene: KS6A6, RPS6KA6
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9UK32

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001650 - fibrillar center
GO:0004672 - protein kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691873

MK03
Mitogen-activated protein kinase 3

3

20

High-throughput

0.858

High

703740

MK01
Mitogen-activated protein kinase 1

2

20

High-throughput

0.789

High

783677

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

17

High-throughput

0.691

High

854377

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.691

High

943628

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

16

High-throughput

0.691

High

1129782

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

High-throughput

0.691

High

1158596

CDC37
Hsp90 co-chaperone Cdc37

1

13

High-throughput

0.691

High

1433322

WNK1
Serine/threonine-protein kinase WNK1

1

17

High-throughput

0.691

High

273595

DJC13
DnaJ homolog subfamily C member 13

1

8

High-throughput

0.656

High

1238500

ZN746
Zinc finger protein 746

1

1

High-throughput

0.656

High

462023

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468894

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

648725

FGFR4
Fibroblast growth factor receptor 4

1

18

High-throughput

0.618

High

1087613

GRSF1
G-rich sequence factor 1

1

8

High-throughput

0.618

High

1460902

ALK
ALK tyrosine kinase receptor

1

15

High-throughput

0.618

High

1460716

OSGI1
Oxidative stress-induced growth inhibitor 1

3

1

High-throughput

0.609

High

1279588

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

2

7

High-throughput

0.606

High

1446248

UBE2T
Ubiquitin-conjugating enzyme E2 T

2

3

High-throughput

0.584

High

995338

CSK2B
Casein kinase II subunit beta

1

8

High-throughput

0.575

High

1460803

GGA2
ADP-ribosylation factor-binding protein GGA2

2

3

High-throughput

0.558

High

1292991

ZN227
Zinc finger protein 227

1

0

High-throughput

0.549

High

652595

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

17

High-throughput

0.541

High

424471

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.536

High

542689

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

637972

NF1
Neurofibromin

1

4

High-throughput

0.536

High

1130511

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.536

High

1450732

DDX18
ATP-dependent RNA helicase DDX18

1

6

High-throughput

0.536

High

1460904

NOC2L
Nucleolar complex protein 2 homolog

1

1

High-throughput

0.536

High

428247

RLA1
Large ribosomal subunit protein P1

1

2

High-throughput

0.508

High

430726

TETN
Tetranectin

1

2

High-throughput

0.508

High

625851

RXRA
Retinoic acid receptor RXR-alpha

1

13

High-throughput

0.508

High

685084

DNMT1
DNA

1

3

High-throughput

0.508

High

877468

MASP1
Mannan-binding lectin serine protease 1

1

4

High-throughput

0.508

High

1023987

EM55
55 kDa erythrocyte membrane protein

1

6

High-throughput

0.508

High

1121628

DHX34
Probable ATP-dependent RNA helicase DHX34

1

1

High-throughput

0.508

High

1352065

MICA1
[F-actin]-monooxygenase MICAL1

1

6

High-throughput

0.508

High

1431496

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

5

High-throughput

0.508

High

423426

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

993804

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.501

High

502170

H2AZ
Histone H2A.Z

1

7

High-throughput

0.489

High

1418423

CDHR2
Cadherin-related family member 2

1

3

High-throughput

0.489

High

282430

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.486

High

451587

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.486

High

964556

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.486

High

1043777

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.486

High

1054814

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.486

High

1154977

ADIRF
Adipogenesis regulatory factor

1

0

High-throughput

0.486

High

1460067

S30BP
SAP30-binding protein

1

0

High-throughput

0.486

High

317030

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.479

High

317943

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

589991

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

696817

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

769470

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

946903

H2B1D
Histone H2B type 1-D

1

19

High-throughput

0.479

High

1142010

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

1460903

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.479

High

965525

LMO4
LIM domain transcription factor LMO4

1

1

High-throughput

0.464

High

1260306

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

2

High-throughput

0.464

High

515809

RGPD1
RANBP2-like and GRIP domain-containing protein 1

1

0

High-throughput

0.458

High

522525

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

1139299

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.458

High

1160611

SMN
Survival motor neuron protein

1

0

High-throughput

0.458

High

1124942

FLOT2
Flotillin-2

1

4

High-throughput

0.437

High

1106324

FZD5
Frizzled-5

1

0

High-throughput

0.265

Low

1323902

SYNE4
Nesprin-4

1

0

High-throughput

0.265

Low

1460901

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025