HitPredict

Interactor 1: JAK3 (P52333)
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Gene: JAK3

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26496610, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1124 Hs			1 303
+	Hs
		337596 ABL1_HUMAN (760-1102): 3.81e-95: 330: 29.48		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		523205 SRC_HUMAN (793-1109): 4.7e-100: 328: 29.25		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		403469 SRC_MOUSE (793-1109): 1.13e-98: 325: 29.56		CHIP_MOUSE (1-303): 1.23e-67: 214: 97.37
+	Hs
		411887 LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		412410 FYN_HUMAN (790-1109): 4.99e-97: 320: 29.60		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		411853 LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50		UN45A_HUMAN (15-161): 8.39e-42: 155: 29.30
+	Hs
		411735 LCK_HUMAN (794-1110): 1.37e-97: 321: 30.50		TOM34_HUMAN (26-117): 9.37e-11: 63.5: 35.87
+	Hs
		616888 JAK1_HUMAN (761-1119): 1.21e-38: 158: 18.62		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		339131 EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		384029 ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		297018 EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34		TOM70_HUMAN (4-212): 8.69e-40: 148: 22.47
+	Hs
		338906 EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34		Q9BPW0_HUMAN (1-259): 2.98e-36: 137: 20.91
+	Dm
		1096401 SHARK_DROME (516-770): 1.7e-21: 103: 29.96		Q9VH81_DROME (4-246): 6.54e-32: 125: 16.87
+	Hs
		338171 EGFR_HUMAN (527-780): 3.22e-18: 92.8: 24.34		PPP5_HUMAN (1-259): 1.3e-35: 135: 20.91
+	Hs
		383952 ERBB2_HUMAN (527-780): 1.84e-13: 77.4: 25.00		Q9BPW0_HUMAN (1-259): 2.98e-36: 137: 20.91
+	Mm
		964566 EGFR_MOUSE (527-780): 4.44e-18: 92.4: 24.34		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22