HitPredict

Interactor 1: PRP43 (P53131)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 (EC 3.6.4.13) (Helicase JA1)
Gene: PRP43

Interactor 2: ERB1 (Q04660)
Ribosome biogenesis protein ERB1 (Eukaryotic ribosome biogenesis protein 1)
Gene: ERB1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	11805837, 16227579
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0005730 - nucleolus GO:0006364 - rRNA processing GO:0042273 - ribosomal large subunit biogenesis
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 767 Sc			1 807
+	Hs
		195393 DHX15_HUMAN (72-743): 0: 753: 65.48		WDR5_HUMAN (330-665): 7.13e-47: 172: 11.53
+	Hs
		209435 DHX8_HUMAN (7-765): 0: 748: 45.07		PLRG1_HUMAN (581-806): 1.32e-46: 176: 14.90
+	Sc
		630874 PRP43_YEAST (1-753): 0: 803: 100.00		NLE1_YEAST (676-807): 3.44e-28: 121: 16.43
+	Zm
		18259 A0A1D6H4I5_MAIZE (7-762): 0: 769: 45.31		A0A1D6J4G2_MAIZE (673-807): 3.08e-24: 109: 13.91
+	Hs
		209480 DHX35_HUMAN (46-738): 0: 651: 43.28		PLRG1_HUMAN (581-806): 1.32e-46: 176: 14.90
+	Hs
		1055474 DHX8_HUMAN (7-765): 0: 748: 45.07		WDR33_HUMAN (593-806): 2.44e-09: 63.3: 19.27
+	Hs
		224824 DHX16_HUMAN (2-750): 0: 702: 42.88		FBXW7_HUMAN (717-807): 4.36e-11: 68.6: 22.83
+	Hs
		1220274 DHX40_HUMAN (94-767): 0: 605: 36.51		WDR33_HUMAN (593-806): 2.44e-09: 63.3: 19.27