HitPredict

Interactor 1: RPAB4 (P53803)
DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)
Gene: POLR2K

Interactor 2: RPC2 (Q9NW08)
DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)
Gene: POLR3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	24981860, 35271311, 33674783
Identification Methods	affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DNA_RNApol_7kD~RNA_pol_Rpb2_1, DNA_RNApol_7kD~RNA_pol_Rpb2_6
Common GO terms	GO:0001056 - RNA polymerase III activity GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol and 1 others more... GO:0008270 - zinc ion binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 58 Hs			1 1133
+	Hs
		676844 RPAB4_HUMAN (1-58): 1.96e-26: 92.1: 100.00		RPB2_HUMAN (14-1127): 0: 1475: 37.52
+	Sc
		606666 RPAB4_YEAST (11-58): 2.14e-17: 69.7: 45.83		RPC2_YEAST (12-1130): 0: 1471: 62.84
+	Sp
		815652 RPAB4_SCHPO (8-58): 1.03e-22: 82.8: 54.90		RPB2_SCHPO (19-1131): 0: 1388: 34.93
+	Sc
		440045 RPAB4_YEAST (11-58): 2.14e-17: 69.7: 45.83		RPB2_YEAST (13-1130): 0: 1382: 36.70
+	Hs
		864991 RPAB4_HUMAN (1-58): 1.96e-26: 92.1: 100.00		RPA2_HUMAN (36-1128): 0: 1159: 29.59
+	Sc
		604566 RPAB4_YEAST (11-58): 2.14e-17: 69.7: 45.83		RPA2_YEAST (12-1129): 0: 1047: 28.42