Protein: METK2
S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)

Gene: METK2, MAT2A
Organism: Homo sapiens
Interactions: 154
UniProt ID: P31153

Gene Ontology (top 5):
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006556 - S-adenosylmethionine biosynthetic process
GO:0006730 - one-carbon metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678678

MAT2B
Methionine adenosyltransferase 2 subunit beta

7

1

Small-scale

0.966

High

678612

METK1
S-adenosylmethionine synthase isoform type-1

5

16

High-throughput

0.926

High

678587

METK2
S-adenosylmethionine synthase isoform type-2

4

15

Small-scale

0.898

High

226633

PRKN
E3 ubiquitin-protein ligase parkin

5

2

High-throughput

0.709

High

678628

DUS6
Dual specificity protein phosphatase 6

3

1

High-throughput

0.633

High

678618

CUL3
Cullin-3

2

0

Small-scale

0.612

High

678653

CSN5
COP9 signalosome complex subunit 5

2

2

High-throughput

0.611

High

678627

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.585

High

209703

PRC1
Protein regulator of cytokinesis 1

2

0

High-throughput

0.580

High

528631

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

411614

LCK
Tyrosine-protein kinase Lck

2

2

High-throughput

0.571

High

412043

FYN
Tyrosine-protein kinase Fyn

2

2

High-throughput

0.571

High

678619

PTK6
Protein-tyrosine kinase 6

2

2

High-throughput

0.571

High

671602

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

678604

CDC42
Cell division control protein 42 homolog

2

0

High-throughput

0.547

High

678613

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

0

High-throughput

0.547

High

678625

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

678601

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

2

High-throughput

0.536

High

678602

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.536

High

678643

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

678662

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

678688

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

678595

RHG25
Rho GTPase-activating protein 25

2

4

High-throughput

0.521

High

678589

HSP74
Heat shock 70 kDa protein 4

1

5

High-throughput

0.515

High

212366

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

1

High-throughput

0.515

High

678650

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.515

High

678664

PELO
Protein pelota homolog

1

1

High-throughput

0.515

High

128461

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

170272

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.513

High

336384

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

174653

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

678609

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

365263

MT2
Metallothionein-2

1

0

High-throughput

0.493

High

678611

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.493

High

678641

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.493

High

678644

CRLF3
Cytokine receptor-like factor 3

1

0

High-throughput

0.493

High

678651

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.493

High

678660

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

1

0

High-throughput

0.493

High

678682

KLF15
Krueppel-like factor 15

1

0

High-throughput

0.493

High

159904

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

148437

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

384349

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

678588

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

678590

GRK5
G protein-coupled receptor kinase 5

1

1

High-throughput

0.479

High

678593

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

678597

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

678605

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

678607

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

678620

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

678623

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

678624

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

678630

RHG21
Rho GTPase-activating protein 21

1

4

High-throughput

0.479

High

678632

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

678639

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.479

High

678646

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.479

High

678647

YAF2
YY1-associated factor 2

1

1

High-throughput

0.479

High

678661

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

1

High-throughput

0.479

High

678666

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

678671

MT21D
Protein N-lysine methyltransferase METTL21D

1

1

High-throughput

0.479

High

678673

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

1

High-throughput

0.479

High

678679

RHG23
Rho GTPase-activating protein 23

1

3

High-throughput

0.479

High

678681

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

678683

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

678686

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

678603

RBM11
Splicing regulator RBM11

1

3

High-throughput

0.470

High

127725

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

294429

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

295595

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.458

High

298196

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

326463

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

381815

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

455129

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

489375

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.458

High

503524

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

617998

COF1
Cofilin-1

1

0

High-throughput

0.458

High

623721

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

650462

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

673451

MPIP2
M-phase inducer phosphatase 2

1

0

High-throughput

0.458

High

678594

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

678596

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

678600

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

678608

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

678614

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

678615

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

678616

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

678622

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.458

High

678633

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

678638

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

678645

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

678648

DOCK3
Dedicator of cytokinesis protein 3

1

0

High-throughput

0.458

High

678652

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

678656

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

678657

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

678668

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

678674

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

678675

ANLN
Anillin

1

0

High-throughput

0.458

High

678676

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

678680

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

678684

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.458

High

678687

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

678629

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

678669

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.445

High

212107

HTSF1
17S U2 SnRNP complex component HTATSF1

1

2

High-throughput

0.437

High

346037

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

569263

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.437

High

659253

DUS1
Dual specificity protein phosphatase 1

1

1

High-throughput

0.437

High

678606

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.437

High

678626

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

678642

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

1

High-throughput

0.437

High

678649

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.437

High

678670

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

371368

ANGI
Angiogenin

1

0

High-throughput

0.426

High

377955

PRIO
Major prion protein

1

0

High-throughput

0.426

High

496403

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

575693

VINC
Vinculin

1

0

High-throughput

0.426

High

678599

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

243998

BRD4
Bromodomain-containing protein 4

2

0

High-throughput

0.305

High

678636

PKHG7
Pleckstrin homology domain-containing family G member 7

2

0

High-throughput

0.298

High

678663

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

234479

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

126768

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.279

Low

452643

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

677878

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

321974

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.268

Low

437277

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.268

Low

554410

GATA1
Erythroid transcription factor

1

0

High-throughput

0.268

Low

678617

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.268

Low

678634

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

678635

CC141
Coiled-coil domain-containing protein 141

1

0

High-throughput

0.268

Low

678658

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.268

Low

57966

TM213
Transmembrane protein 213

1

0

High-throughput

0.251

Low

100529

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

241987

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

351954

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

552035

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

654105

CALX
Calnexin

1

0

High-throughput

0.249

Low

678591

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

678592

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

678598

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

678610

H31
Histone H3.1

1

0

High-throughput

0.249

Low

678621

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

678631

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

678637

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

678640

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

678654

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.249

Low

678655

RAB8B
Ras-related protein Rab-8B

1

0

High-throughput

0.249

Low

678659

VCIP1
Deubiquitinating protein VCPIP1

1

0

Small-scale

0.249

Low

678665

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

678667

ARP6
Actin-related protein 6

1

0

High-throughput

0.249

Low

678672

MAGF1
Melanoma-associated antigen F1

1

0

Small-scale

0.249

Low

678677

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

678685

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

943

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024