HitPredict

Interactor 1: OCA2 (P53949)
Tyrosine-protein phosphatase-like protein OCA2 (Oxidant-induced cell-cycle arrest protein 2)
Gene: OCA2

Interactor 2: SIW14 (P53965)
Inositol phosphatase SIW14 (EC 3.6.1.52) (5-PP-InsP phosphatase) (Inositol pyrophosphate phosphatase SIW14) (Oxidant-induced cell-cycle arrest protein 3) (Synthetic interaction with WHI2 protein 14)
Gene: SIW14

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.940

Property	Details
Experiments	10688190, 11283351, 10655498, 18719252, 37968396, 16429126
Identification Methods	two hybrid, two hybrid pooling approach, affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Y_phosphatase2~Y_phosphatase2
Common GO terms	GO:0005737 - cytoplasm GO:0016791 - phosphatase activity GO:0052840 - inositol diphosphate tetrakisphosphate diphosphatase activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 197 Sc			1 281
+	Sc
		866755 OCA6_YEAST (1-190): 7.18e-69: 211: 22.64		SIW14_YEAST (1-281): 6.16e-174: 482: 100.00
+	Sc
		842769 OCA2_YEAST (1-197): 9.47e-102: 293: 100.00		OCA1_YEAST (108-277): 1.35e-75: 232: 32.96
+	Sc
		866676 OCA2_YEAST (1-197): 9.47e-102: 293: 100.00		OCA6_YEAST (116-281): 3.93e-53: 174: 23.91
+	Sc
		842773 OCA6_YEAST (1-190): 7.18e-69: 211: 22.64		OCA1_YEAST (108-277): 1.35e-75: 232: 32.96
+	At
		1195865 DSP2_ARATH (1-154): 1.05e-65: 204: 28.80		DSP2_ARATH (115-269): 5.9e-77: 236: 43.92
+	Sc
		842770 SIW14_YEAST (2-154): 1.15e-65: 204: 36.54		OCA1_YEAST (108-277): 1.35e-75: 232: 32.96