HitPredict

Interactor 1: MLC2 (P54357)
Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain)
Gene: Mlc-c

Interactor 2: MYSN (Q99323)
Myosin heavy chain, non-muscle (Myosin II) (Non-muscle MHC) (Zipper protein)
Gene: zip

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	16917818, 22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EF-hand_6~IQ, EF-hand_6~Myosin_head, EF-hand_7~IQ, EF-hand_7~Myosin_head, EF-hand_7~Myosin_N
Common GO terms	GO:0005829 - cytosol GO:0016460 - myosin II complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 147 Dm			1 2057
+	Ce
		104561 CALM_CAEEL (3-146): 1.26e-46: 149: 42.76		G5EBY3_CAEEL (82-2031): 0: 1371: 46.74
+	Hs
		538642 MYL6B_HUMAN (3-146): 1.59e-47: 154: 53.38		MYH9_HUMAN (1145-2057): 5.56e-58: 224: 16.63
+	Gg
		361265 MYL6_CHICK (1-147): 3.11e-55: 171: 54.31		MYH11_CHICK (1165-2056): 2.82e-52: 206: 16.40
+	Hs
		538643 MYL6B_HUMAN (3-146): 1.59e-47: 154: 53.38		MYH10_HUMAN (1165-2057): 6.8e-56: 218: 15.52
+	Hs
		724737 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH9_HUMAN (1145-2057): 5.56e-58: 224: 16.63
+	Hs
		648467 CALL3_HUMAN (3-146): 5.6e-44: 143: 41.38		MYH9_HUMAN (1145-2057): 5.56e-58: 224: 16.63
+	Hs
		725124 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH10_HUMAN (1165-2057): 6.8e-56: 218: 15.52
+	Hs
		728458 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH11_HUMAN (1164-2057): 2.72e-55: 216: 16.54
+	Hs
		409452 MYL1_HUMAN (4-146): 3.1e-42: 140: 53.06		MYH10_HUMAN (1165-2057): 6.8e-56: 218: 15.52
+	Hs
		441665 MYL3_HUMAN (4-146): 8.71e-40: 134: 48.99		MYH9_HUMAN (1145-2057): 5.56e-58: 224: 16.63
+	Ce
		522310 MLE_CAEEL (1-147): 5.57e-32: 112: 42.67		MYO3_CAEEL (1043-2057): 3.96e-63: 241: 16.55
+	Hs
		441666 MYL3_HUMAN (4-146): 8.71e-40: 134: 48.99		MYH10_HUMAN (1165-2057): 6.8e-56: 218: 15.52
+	Ce
		361113 MLE_CAEEL (1-147): 5.57e-32: 112: 42.67		MYO4_CAEEL (1057-2057): 9.38e-62: 237: 16.07
+	Hs
		538680 MYL6B_HUMAN (3-146): 1.59e-47: 154: 53.38		MYH14_HUMAN (1169-2057): 1.71e-48: 193: 15.11
+	Hs
		891551 MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64		MYH14_HUMAN (1169-2057): 1.71e-48: 193: 15.11
+	Hs
		441674 MYL3_HUMAN (4-146): 8.71e-40: 134: 48.99		MYH14_HUMAN (1169-2057): 1.71e-48: 193: 15.11
+	Ce
		361125 MLE_CAEEL (1-147): 5.57e-32: 112: 42.67		MYO1_CAEEL (822-1368): 5.61e-16: 87.1: 13.23