Protein: FHL5
Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis)

Gene: FHL5
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q5TD97

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0008270 - zinc ion binding
GO:0030018 - Z disc
GO:0045944 - positive regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1216161

PDLI7
PDZ and LIM domain protein 7

3

19

High-throughput

0.861

High

681832

RBTN2
Rhombotin-2

2

20

High-throughput

0.783

High

1216166

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

2

2

High-throughput

0.783

High

913778

ZN131
Zinc finger protein 131

5

17

High-throughput

0.717

High

1216154

SCNM1
Sodium channel modifier 1

5

3

High-throughput

0.717

High

270505

SLIT1
Slit homolog 1 protein

2

1

High-throughput

0.700

High

1186105

ANR55
Ankyrin repeat domain-containing protein 55

2

12

High-throughput

0.700

High

1216155

HPLN2
Hyaluronan and proteoglycan link protein 2

2

2

High-throughput

0.700

High

1216121

ATOSB
Atos homolog protein B

4

2

High-throughput

0.688

High

345188

ZMYM6
Zinc finger MYM-type protein 6

3

7

High-throughput

0.667

High

1210714

ZMYM1
Zinc finger MYM-type protein 1

3

7

High-throughput

0.667

High

1216129

TAXB1
Tax1-binding protein 1

3

12

High-throughput

0.667

High

354860

DNAL4
Dynein axonemal light chain 4

5

2

High-throughput

0.653

High

1040632

CREM
cAMP-responsive element modulator

2

9

Small-scale

0.633

High

1216117

FHL5
Four and a half LIM domains protein 5

1

16

Small-scale

0.621

High

1216135

BANP
Protein BANP

3

4

High-throughput

0.609

High

49566

FEZF1
Fez family zinc finger protein 1

2

11

High-throughput

0.606

High

140304

SDCB1
Syntenin-1

2

6

High-throughput

0.606

High

473434

HCK
Tyrosine-protein kinase HCK

2

20

High-throughput

0.606

High

585049

ZN250
Zinc finger protein 250

2

5

High-throughput

0.606

High

600231

ZNF23
Zinc finger protein 23

2

3

High-throughput

0.606

High

604828

HXB9
Homeobox protein Hox-B9

2

7

High-throughput

0.606

High

733164

OTX1
Homeobox protein OTX1

2

6

High-throughput

0.606

High

885287

HXA1
Homeobox protein Hox-A1

2

8

High-throughput

0.606

High

1051379

ZBT16
Zinc finger and BTB domain-containing protein 16

2

9

High-throughput

0.606

High

1109293

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

1

High-throughput

0.606

High

1156258

ZN124
Zinc finger protein 124

2

12

High-throughput

0.606

High

1180142

QRIC1
Transcriptional regulator QRICH1

2

13

High-throughput

0.606

High

1186343

ZN792
Zinc finger protein 792

2

11

High-throughput

0.606

High

1204855

ZN766
Zinc finger protein 766

2

8

High-throughput

0.606

High

1216119

ZN613
Zinc finger protein 613

2

2

High-throughput

0.606

High

1216123

NUFP2
FMR1-interacting protein NUFIP2

2

1

High-throughput

0.606

High

1216128

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

4

High-throughput

0.606

High

1216132

ZN440
Zinc finger protein 440

2

8

High-throughput

0.606

High

1216140

ZN417
Zinc finger protein 417

2

10

High-throughput

0.606

High

1216142

ZN564
Zinc finger protein 564

2

7

High-throughput

0.606

High

1216143

MYOZ3
Myozenin-3

2

1

High-throughput

0.606

High

1216147

ZN764
Zinc finger protein 764

2

10

High-throughput

0.606

High

1216150

ZN587
Zinc finger protein 587

2

10

High-throughput

0.606

High

1216153

ZN251
Zinc finger protein 251

2

6

High-throughput

0.606

High

1216156

ZN408
Zinc finger protein 408

2

12

High-throughput

0.606

High

1216157

PKHA2
Pleckstrin homology domain-containing family A member 2

2

10

High-throughput

0.606

High

1216158

NEK6
Serine/threonine-protein kinase Nek6

2

2

High-throughput

0.606

High

1216159

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

1

High-throughput

0.606

High

1216164

ABI2
Abl interactor 2

2

20

High-throughput

0.606

High

1216165

ZN581
Zinc finger protein 581

2

5

High-throughput

0.606

High

1216125

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

6

High-throughput

0.594

High

211648

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.580

High

479829

GSTP1
Glutathione S-transferase P

2

0

High-throughput

0.580

High

1098562

GPS2
G protein pathway suppressor 2

2

0

High-throughput

0.580

High

1146375

LRC41
Leucine-rich repeat-containing protein 41

2

0

High-throughput

0.580

High

1216122

HDX
Highly divergent homeobox

2

0

High-throughput

0.580

High

1216145

MGN2
Protein mago nashi homolog 2

2

0

High-throughput

0.580

High

1216148

IP6K3
Inositol hexakisphosphate kinase 3

2

0

High-throughput

0.580

High

1216162

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

0

High-throughput

0.580

High

1216144

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

11

High-throughput

0.555

High

61022

DCD2B
Doublecortin domain-containing protein 2B

2

2

High-throughput

0.553

High

209897

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

4

High-throughput

0.553

High

221369

SPY1
Protein sprouty homolog 1

2

5

High-throughput

0.553

High

323879

SC31A
Protein transport protein Sec31A

2

3

High-throughput

0.553

High

638848

AGT1
Alanine--glyoxylate aminotransferase

2

1

High-throughput

0.553

High

699456

PROP
Properdin

2

5

High-throughput

0.553

High

922358

CRBA2
Beta-crystallin A2

2

4

High-throughput

0.553

High

1119739

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

13

High-throughput

0.553

High

1193108

PKHN1
Pleckstrin homology domain-containing family N member 1

2

9

High-throughput

0.553

High

1216118

PPR18
Phostensin

2

12

High-throughput

0.553

High

1216120

ATL5
ADAMTS-like protein 5

2

4

High-throughput

0.553

High

1216124

SAXO4
Stabilizer of axonemal microtubules 4

2

2

High-throughput

0.553

High

1216130

CD20B
Cell division cycle protein 20 homolog B

2

4

High-throughput

0.553

High

1216131

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.553

High

1216133

SAXO1
Stabilizer of axonemal microtubules 1

2

3

High-throughput

0.553

High

1216136

CNNM3
Metal transporter CNNM3

2

1

High-throughput

0.553

High

1216137

CTSR1
Cation channel sperm-associated protein 1

2

8

High-throughput

0.553

High

1216138

GAR6
Golgi-associated RAB2 interactor protein 6

2

2

High-throughput

0.553

High

1216141

R3GEF
Guanine nucleotide exchange factor for Rab-3A

2

2

High-throughput

0.553

High

1216151

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

2

4

High-throughput

0.553

High

1216152

THIOM
Thioredoxin, mitochondrial

2

2

High-throughput

0.553

High

1216168

RAB26
Ras-related protein Rab-26

2

3

High-throughput

0.553

High

1216169

DLGP4
Disks large-associated protein 4

2

5

High-throughput

0.553

High

593130

CREB1
Cyclic AMP-responsive element-binding protein 1

1

5

Small-scale

0.552

High

799929

COIL
Coilin

1

1

High-throughput

0.541

High

1216163

ZN446
Zinc finger protein 446

1

11

High-throughput

0.541

High

922386

CRBA4
Beta-crystallin A4

1

4

High-throughput

0.523

High

69896

A8KA13
B-cell CLL/lymphoma 6 member B protein

1

9

High-throughput

0.515

High

167282

KLF11
Krueppel-like factor 11

1

14

High-throughput

0.515

High

505720

ZN688
Zinc finger protein 688

1

15

High-throughput

0.481

High

1216134

BCL6B
B-cell CLL/lymphoma 6 member B protein

1

10

High-throughput

0.481

High

551090

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.479

High

600315

ZNF24
Zinc finger protein 24

1

11

High-throughput

0.479

High

1216127

KAISO
Transcriptional regulator Kaiso

1

12

High-throughput

0.479

High

109418

G5E9A7
DM1 locus, WD repeat containing

1

6

High-throughput

0.470

High

1193601

Q49AR9
ANKS1A protein

1

3

High-throughput

0.470

High

1216146

COQA1
Collagen alpha-1(XXVI) chain

1

2

High-throughput

0.470

High

3541

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

10

High-throughput

0.457

High

959489

YPEL3
Protein yippee-like 3

1

2

High-throughput

0.439

High

3628

A0A0S2Z6P0
Zinc finger protein 688 isoform 2

1

7

High-throughput

0.417

High

1216126

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

3

0

High-throughput

0.347

High

1216139

CEP76
Centrosomal protein of 76 kDa

3

0

High-throughput

0.347

High

296709

TUSC2
Tumor suppressor candidate 2

2

0

High-throughput

0.316

High

334421

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

992495

RS21
Small ribosomal subunit protein eS21

2

0

High-throughput

0.316

High

1216149

BBC3B
Bcl-2-binding component 3, isoforms 3/4

2

0

High-throughput

0.316

High

1216160

NPDC1
Neural proliferation differentiation and control protein 1

2

0

High-throughput

0.316

High

1216167

CATZ
Cathepsin Z

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025