HitPredict

Interactor 1: PDI (P54399)
Protein disulfide-isomerase (PDI) (dPDI) (EC 5.3.4.1)
Gene: PDI

Interactor 2: THIO2 (Q9V429)
Thioredoxin-2 (DmTrx-2)
Gene: Trx-2

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Thioredoxin~Thioredoxin, Thioredoxin~Thioredoxin_6
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 496 Dm			1 106
+	Hs
		423342 PDIA1_HUMAN (23-471): 9.18e-143: 421: 56.07		THIOM_HUMAN (5-106): 3.5e-33: 114: 37.86
+	Dm
		870452 PDI_DROME (1-496): 7.24e-147: 431: 100.00		PDIA6_DROME (3-94): 5.14e-26: 101: 18.09
+	Hs
		423123 PDIA1_HUMAN (23-471): 9.18e-143: 421: 56.07		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02
+	Ce
		1089129 PDI1_CAEEL (7-489): 1.64e-118: 358: 40.66		PDI2_CAEEL (3-103): 1.29e-24: 97.9: 23.81
+	At
		1226367 PDI11_ARATH (3-475): 1.37e-106: 328: 35.11		TRXY2_ARATH (7-106): 2.9e-34: 117: 35.64
+	At
		1114800 PDI11_ARATH (3-475): 1.37e-106: 328: 35.11		TRXH3_ARATH (19-93): 5.01e-17: 72: 48.00
+	Hs
		531830 PDIA5_HUMAN (3-496): 3.21e-75: 247: 17.68		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02
+	Mm
		956780 ERP44_MOUSE (363-493): 6.76e-27: 114: 20.44		THIOM_MOUSE (5-106): 1.18e-32: 113: 38.84
+	Hs
		671722 PDIA3_HUMAN (352-494): 3.45e-30: 125: 29.66		PDIA3_HUMAN (3-104): 7.47e-26: 101: 24.30
+	Hs
		531910 TXND5_HUMAN (7-137): 5.74e-31: 126: 35.61		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02
+	Hs
		531739 PDIA3_HUMAN (352-494): 3.45e-30: 125: 29.66		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02
+	Mm
		1265101 ERP44_MOUSE (363-493): 6.76e-27: 114: 20.44		TXND5_MOUSE (24-106): 3.46e-27: 104: 26.14
+	Mm
		653446 ERP44_MOUSE (363-493): 6.76e-27: 114: 20.44		PDIA3_MOUSE (3-104): 3.52e-25: 99.4: 24.30
+	Hs
		531966 ERP44_HUMAN (363-493): 3.95e-26: 111: 18.25		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02
+	Rn
		751960 PDIA4_RAT (367-494): 1.56e-24: 109: 32.82		PDIA4_RAT (3-105): 6.97e-23: 93.2: 22.02
+	Nc
		1186329 Q7S399_NEUCR (16-145): 7.78e-21: 97.1: 33.09		ERP38_NEUCR (3-105): 2.24e-27: 104: 26.61
+	Hs
		671862 DJC10_HUMAN (264-479): 3.84e-21: 99.1: 16.20		PDIA3_HUMAN (3-104): 7.47e-26: 101: 24.30
+	Hs
		531897 DJC10_HUMAN (264-479): 3.84e-21: 99.1: 16.20		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02
+	Hs
		531837 PDIA6_HUMAN (372-461): 5.62e-09: 60.1: 35.56		PDIA4_HUMAN (3-105): 5.27e-25: 99.4: 22.02