Protein: PIAS4
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma)

Gene: PIAS4
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q8N2W9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001942 - hair follicle development
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

902668

SUMO2
Small ubiquitin-related modifier 2

5

20

Small-scale

0.924

High

930294

UBC9
SUMO-conjugating enzyme UBC9

5

14

Small-scale

0.916

High

1231881

NEMO
NF-kappa-B essential modulator

5

4

Small-scale

0.702

High

455648

PARP1
Poly [ADP-ribose] polymerase 1

3

3

Small-scale

0.681

High

1035500

SMAD4
Mothers against decapentaplegic homolog 4

3

16

Small-scale

0.669

High

1222465

SLX4
Structure-specific endonuclease subunit SLX4

3

8

High-throughput

0.656

High

387087

P53
Cellular tumor antigen p53

3

10

Small-scale

0.650

High

1231825

PIAS4
E3 SUMO-protein ligase PIAS4

1

9

Small-scale

0.647

High

983871

KPCZ
Protein kinase C zeta type

2

4

Small-scale

0.643

High

973363

TOP2B
DNA topoisomerase 2-beta

2

3

Small-scale

0.639

High

1231863

CAH10
Carbonic anhydrase-related protein 10

3

0

High-throughput

0.638

High

551202

ITF2
Transcription factor 4

3

0

Small-scale

0.636

High

950220

SMAD3
Mothers against decapentaplegic homolog 3

2

16

Small-scale

0.631

High

791754

HD
Huntingtin

2

1

High-throughput

0.631

High

509056

TOP2A
DNA topoisomerase 2-alpha

2

3

Small-scale

0.629

High

167374

SMAD7
Mothers against decapentaplegic homolog 7

2

16

Small-scale

0.627

High

1078729

SMAD1
Mothers against decapentaplegic homolog 1

2

16

Small-scale

0.627

High

896334

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.622

High

278306

PIAS2
E3 SUMO-protein ligase PIAS2

1

9

High-throughput

0.621

High

928135

SUMO1
Small ubiquitin-related modifier 1

1

20

Small-scale

0.621

High

1078585

SMAD2
Mothers against decapentaplegic homolog 2

2

16

Small-scale

0.620

High

1231830

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

9

Small-scale

0.618

High

554477

GATA1
Erythroid transcription factor

2

2

Small-scale

0.611

High

267667

TADA3
Transcriptional adapter 3

2

0

High-throughput

0.609

High

135032

TRI38
E3 ubiquitin-protein ligase TRIM38

2

7

High-throughput

0.606

High

1231828

ZBT34
Zinc finger and BTB domain-containing protein 34

2

5

High-throughput

0.606

High

487590

ANDR
Androgen receptor

2

20

Small-scale

0.602

High

772053

VHL
von Hippel-Lindau disease tumor suppressor

2

0

Small-scale

0.598

High

966985

SATB1
DNA-binding protein SATB1

2

4

Small-scale

0.595

High

879136

SUMO3
Small ubiquitin-related modifier 3

1

20

High-throughput

0.590

High

510028

ERR1
Steroid hormone receptor ERR1

2

18

Small-scale

0.586

High

542039

ETS1
Protein C-ets-1

2

14

Small-scale

0.584

High

668825

PML
Protein PML

2

7

High-throughput

0.584

High

1134538

LCE1D
Late cornified envelope protein 1D

2

0

High-throughput

0.580

High

1231873

LEF1
Lymphoid enhancer-binding factor 1

1

10

Small-scale

0.573

High

1231848

GFI1
Zinc finger protein Gfi-1

2

2

Small-scale

0.565

High

165288

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

1

4

Small-scale

0.561

High

208788

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.561

High

508614

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.561

High

206968

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.552

High

536921

TRI27
Zinc finger protein RFP

1

7

Small-scale

0.552

High

1025459

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.541

High

199357

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

Small-scale

0.537

High

841511

KNTC1
Kinetochore-associated protein 1

1

0

Small-scale

0.537

High

1231849

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.537

High

147264

TXND9
Thioredoxin domain-containing protein 9

1

1

High-throughput

0.536

High

170420

TIF1A
Transcription intermediary factor 1-alpha

1

10

High-throughput

0.536

High

782361

KDM5C
Lysine-specific demethylase 5C

1

2

High-throughput

0.536

High

962861

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.536

High

1065649

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

High-throughput

0.536

High

1131588

ZMYM1
Zinc finger MYM-type protein 1

1

6

High-throughput

0.536

High

1167108

MCAF1
Activating transcription factor 7-interacting protein 1

1

3

High-throughput

0.536

High

1188030

SETX
Probable helicase senataxin

1

2

High-throughput

0.536

High

1218681

MGAP
MAX gene-associated protein

1

1

High-throughput

0.536

High

1231839

XPF
DNA repair endonuclease XPF

1

2

High-throughput

0.536

High

1231841

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.536

High

1231867

SENP1
Sentrin-specific protease 1

1

2

High-throughput

0.536

High

1231879

ARIP4
Helicase ARIP4

1

7

High-throughput

0.536

High

1056437

IRF3
Interferon regulatory factor 3

1

3

Small-scale

0.534

High

1231840

IRF7
Interferon regulatory factor 7

1

3

Small-scale

0.534

High

978806

TF65
Transcription factor p65

1

7

Small-scale

0.515

High

1067047

BRD3
Bromodomain-containing protein 3

1

6

High-throughput

0.515

High

111184

I6L9F6
NEFL protein

1

8

High-throughput

0.515

High

235949

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

High-throughput

0.515

High

322011

ZMYM6
Zinc finger MYM-type protein 6

1

4

High-throughput

0.515

High

446908

HXC4
Homeobox protein Hox-C4

1

4

High-throughput

0.515

High

985558

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

1054163

BECN1
Beclin-1

1

1

High-throughput

0.515

High

1169550

CC141
Coiled-coil domain-containing protein 141

1

5

High-throughput

0.515

High

1231826

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

2

High-throughput

0.515

High

1231832

GABP2
GA-binding protein subunit beta-2

1

2

High-throughput

0.515

High

1231833

MAGC3
Melanoma-associated antigen C3

1

2

High-throughput

0.515

High

1231834

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.515

High

1231871

KLF15
Krueppel-like factor 15

1

3

High-throughput

0.515

High

887250

ZN445
Zinc finger protein 445

1

0

High-throughput

0.513

High

943737

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.513

High

1051742

NPAT
Protein NPAT

1

0

High-throughput

0.513

High

1075293

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.513

High

1123282

PKHG4
Puratrophin-1

1

0

High-throughput

0.513

High

1161120

ZCH12
Zinc finger CCHC domain-containing protein 12

1

0

High-throughput

0.513

High

1191128

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

High-throughput

0.513

High

1199068

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

High-throughput

0.513

High

1223158

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.513

High

1231829

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.513

High

1231837

RREB1
Ras-responsive element-binding protein 1

1

0

High-throughput

0.513

High

1231854

FANCJ
Fanconi anemia group J protein

1

0

High-throughput

0.513

High

1231859

ZN644
Zinc finger protein 644

1

0

High-throughput

0.513

High

1231860

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

1231862

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

1231876

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.513

High

154838

TCRG1
Transcription elongation regulator 1

1

5

High-throughput

0.508

High

263726

PR40A
Pre-mRNA-processing factor 40 homolog A

1

6

High-throughput

0.508

High

422232

NFL
Neurofilament light polypeptide

1

8

High-throughput

0.508

High

443652

VIME
Vimentin

1

7

High-throughput

0.508

High

518709

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.508

High

521378

SKIL
Ski-like protein

1

2

High-throughput

0.508

High

1018579

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.508

High

1231847

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.508

High

1231850

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.508

High

1231857

MAGH1
Melanoma-associated antigen H1

1

3

High-throughput

0.508

High

1231875

ZHX1
Zinc fingers and homeoboxes protein 1

1

2

High-throughput

0.508

High

653914

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

1

Small-scale

0.501

High

749673

BRCA1
Breast cancer type 1 susceptibility protein

1

11

Small-scale

0.501

High

782594

HNF4A
Hepatocyte nuclear factor 4-alpha

1

13

Small-scale

0.501

High

831909

CEBPD
CCAAT/enhancer-binding protein delta

1

6

Small-scale

0.501

High

995928

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

1

Small-scale

0.501

High

1023297

TRI32
E3 ubiquitin-protein ligase TRIM32

1

11

Small-scale

0.501

High

1038531

HDAC1
Histone deacetylase 1

1

3

Small-scale

0.501

High

1056886

MDC1
Mediator of DNA damage checkpoint protein 1

1

6

Small-scale

0.501

High

1150311

PLAG1
Zinc finger protein PLAG1

1

6

Small-scale

0.501

High

1231838

HDAC2
Histone deacetylase 2

1

3

Small-scale

0.501

High

397664

IPSP
Plasma serine protease inhibitor

1

1

High-throughput

0.494

High

130164

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.493

High

216541

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.493

High

236642

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

1

0

High-throughput

0.493

High

245465

SHOX2
Short stature homeobox protein 2

1

0

High-throughput

0.493

High

265225

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

395170

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

653656

CALR
Calreticulin

1

0

High-throughput

0.493

High

739187

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

882944

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.493

High

945811

IN35
Interferon-induced 35 kDa protein

1

0

High-throughput

0.493

High

1058190

LPIN1
Phosphatidate phosphatase LPIN1

1

0

High-throughput

0.493

High

1067684

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

1202900

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.493

High

1216610

CRLF3
Cytokine receptor-like factor 3

1

0

High-throughput

0.493

High

1231835

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.493

High

1231845

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.493

High

1231846

BOD1
Biorientation of chromosomes in cell division protein 1

1

0

High-throughput

0.493

High

1231861

MYOZ1
Myozenin-1

1

0

High-throughput

0.493

High

1231866

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.493

High

1231874

ITBP2
Integrin beta-1-binding protein 2

1

0

High-throughput

0.493

High

1231880

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.493

High

201033

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

1

High-throughput

0.489

High

1216092

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.488

High

309862

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.486

High

833772

CLK1
Dual specificity protein kinase CLK1

1

0

High-throughput

0.486

High

1060824

IMB1
Importin subunit beta-1

1

0

High-throughput

0.486

High

1133078

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.486

High

1231858

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

0

High-throughput

0.486

High

163621

BTAF1
TATA-binding protein-associated factor 172

1

6

High-throughput

0.481

High

408869

K1C18
Keratin, type I cytoskeletal 18

1

3

High-throughput

0.481

High

521575

ACTN1
Alpha-actinin-1

1

3

High-throughput

0.481

High

553170

RFA2
Replication protein A 32 kDa subunit

1

4

Small-scale

0.481

High

1138275

MYOME
Myomegalin

1

4

High-throughput

0.481

High

1231827

SERB1
SERPINE1 mRNA-binding protein 1

1

3

Small-scale

0.481

High

1231842

OPTN
Optineurin

1

5

High-throughput

0.481

High

1231853

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

2

High-throughput

0.481

High

153724

ANM5
Protein arginine N-methyltransferase 5

1

2

Small-scale

0.479

High

197762

CRX
Cone-rod homeobox protein

1

5

High-throughput

0.479

High

319918

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

Small-scale

0.479

High

347309

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

360149

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

470088

H2AZ
Histone H2A.Z

1

3

High-throughput

0.479

High

523877

XRCC6
X-ray repair cross-complementing protein 6

1

3

Small-scale

0.479

High

524983

XRCC5
X-ray repair cross-complementing protein 5

1

3

Small-scale

0.479

High

782804

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.479

High

828297

CENPA
Histone H3-like centromeric protein A

1

11

High-throughput

0.479

High

918518

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

934975

H31
Histone H3.1

1

11

High-throughput

0.479

High

941155

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

952464

H33
Histone H3.3

1

11

High-throughput

0.479

High

986943

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

1027117

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

1070982

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

1

Small-scale

0.479

High

1085606

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

1137529

RIF1
Telomere-associated protein RIF1

1

4

Small-scale

0.479

High

1231855

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1231864

FANCI
Fanconi anemia group I protein

1

1

Small-scale

0.479

High

1231868

ZMYM2
Zinc finger MYM-type protein 2

1

4

High-throughput

0.479

High

1231869

REV1
DNA repair protein REV1

1

3

Small-scale

0.479

High

1231870

KDM5B
Lysine-specific demethylase 5B

1

2

Small-scale

0.479

High

1231877

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

365214

FRIH
Ferritin heavy chain

1

0

High-throughput

0.460

High

375974

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.460

High

870309

OAZ1
Ornithine decarboxylase antizyme 1

1

0

High-throughput

0.460

High

1231851

SH3G3
Endophilin-A3

1

0

High-throughput

0.460

High

1231872

PHF11
PHD finger protein 11

1

0

High-throughput

0.460

High

122878

MEN1
Menin

1

0

Small-scale

0.458

High

176616

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

602860

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.458

High

652915

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

974607

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

Small-scale

0.458

High

1156355

ZN746
Zinc finger protein 746

1

0

Small-scale

0.458

High

1231856

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1231831

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.457

High

497293

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

197349

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.439

High

1167381

MPRIP
Myosin phosphatase Rho-interacting protein

1

3

High-throughput

0.439

High

1029375

I15RA
Interleukin-15 receptor subunit alpha

1

0

High-throughput

0.282

High

1079942

RB11B
Ras-related protein Rab-11B

1

0

High-throughput

0.279

Low

1231843

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.279

Low

1231844

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.279

Low

1231865

TM160
Transmembrane protein 160

1

0

High-throughput

0.279

Low

1231878

HBS1L
HBS1-like protein

1

0

High-throughput

0.279

Low

94679

F2Z2M7
Polypeptide N-acetylgalactosaminyltransferase 10

1

0

High-throughput

0.268

Low

522055

CADH1
Cadherin-1

1

0

High-throughput

0.268

Low

1158423

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

1231836

LAR4B
La-related protein 4B

1

0

High-throughput

0.268

Low

1231852

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.268

Low

597402

PTN
Pleiotrophin

1

0

High-throughput

0.265

Low

1088555

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.265

Low

527612

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024