Protein: SC6A1
Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1)

Gene: SC6A1, Slc6a1
Organism: Mus musculus
Interactions: 68
UniProt ID: P31648

Gene Ontology (top 5):
GO:0005283 - amino acid:sodium symporter activity
GO:0005332 - gamma-aminobutyric acid:sodium:chloride symporter activity
GO:0005886 - plasma membrane
GO:0007613 - memory
GO:0008306 - associative learning

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

727583

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

9

High-throughput

0.618

High

727598

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.536

High

64321

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

2

High-throughput

0.479

High

92673

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

2

High-throughput

0.479

High

97363

PRRT2
Proline-rich transmembrane protein 2

1

1

High-throughput

0.479

High

108481

G3X9H5
Huntingtin

1

2

High-throughput

0.479

High

312108

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

1

High-throughput

0.479

High

530711

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.479

High

559558

SCD2
Stearoyl-CoA desaturase 2

1

1

High-throughput

0.479

High

663060

GRIA2
Glutamate receptor 2

1

4

High-throughput

0.479

High

723278

SSR3
Somatostatin receptor type 3

1

3

High-throughput

0.479

High

727584

CALX
Calnexin

1

17

High-throughput

0.479

High

727585

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.479

High

727592

STX1B
Syntaxin-1B

1

15

High-throughput

0.479

High

727593

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.479

High

727594

VAMP2
Vesicle-associated membrane protein 2

1

3

High-throughput

0.479

High

727606

PITM2
Membrane-associated phosphatidylinositol transfer protein 2

1

2

High-throughput

0.479

High

727612

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.479

High

727618

LNX2
Ligand of Numb protein X 2

1

20

High-throughput

0.479

High

727619

SYUB
Beta-synuclein

1

10

High-throughput

0.479

High

727623

MYO5A
Unconventional myosin-Va

1

1

High-throughput

0.479

High

727625

RTN4
Reticulon-4

1

5

High-throughput

0.479

High

727627

ACBG1
Long-chain-fatty-acid--CoA ligase ACSBG1

1

5

High-throughput

0.479

High

727633

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

2

High-throughput

0.479

High

727634

VAPA
Vesicle-associated membrane protein-associated protein A

1

3

High-throughput

0.479

High

727635

E41L3
Band 4.1-like protein 3

1

6

High-throughput

0.479

High

578742

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

727614

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.458

High

727629

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.458

High

59050

F1712
Protein FAM171A2

1

1

High-throughput

0.437

High

108270

G3X8Y3

1

1

High-throughput

0.437

High

266756

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.437

High

727586

H15
Histone H1.5

1

1

High-throughput

0.437

High

727590

ABCD3
ATP-binding cassette sub-family D member 3

1

9

High-throughput

0.437

High

727591

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.437

High

727596

F171B
Protein FAM171B

1

1

High-throughput

0.437

High

727597

PSD3
PH and SEC7 domain-containing protein 3

1

1

High-throughput

0.437

High

727599

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.437

High

727601

PRDX2
Peroxiredoxin-2

1

4

High-throughput

0.437

High

727602

KTN1
Kinectin

1

3

High-throughput

0.437

High

727603

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.437

High

727604

RALY
RNA-binding protein Raly

1

1

High-throughput

0.437

High

727607

TNC18
Trinucleotide repeat-containing gene 18 protein

1

2

High-throughput

0.437

High

727608

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

2

High-throughput

0.437

High

727611

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.437

High

727613

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.437

High

727616

DGKG
Diacylglycerol kinase gamma

1

8

High-throughput

0.437

High

727620

FADS1
Acyl-CoA

1

3

High-throughput

0.437

High

727622

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

High-throughput

0.437

High

727626

RRBP1
Ribosome-binding protein 1

1

5

High-throughput

0.437

High

727628

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

3

High-throughput

0.437

High

727630

RUFY3
Protein RUFY3

1

1

High-throughput

0.437

High

727631

RTN3
Reticulon-3

1

5

High-throughput

0.437

High

531204

GSTM1
Glutathione S-transferase Mu 1

1

0

High-throughput

0.249

Low

727587

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

727588

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.249

Low

727589

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low

727595

GDN
Glia-derived nexin

1

0

High-throughput

0.249

Low

727600

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

727605

SPKAP
A-kinase anchor protein SPHKAP

1

0

High-throughput

0.249

Low

727609

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

727610

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.249

Low

727615

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.249

Low

727617

NCALD
Neurocalcin-delta

1

0

High-throughput

0.249

Low

727621

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

727624

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.249

Low

727632

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025