HitPredict

Interactor 1: AAPK1 (P54645)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: Prkaa1

Interactor 2: AAKB1 (P80386)
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) (5'-AMP-activated protein kinase 40 kDa subunit)
Gene: Prkab1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.876

The method score is based on:

Property Details
Experiments 24625528, 25066137, 21481774
Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains AMPK1_CBM~AdenylateSensor, AMPKBI~AdenylateSensor, AMPK1_CBM~Pkinase, AMPKBI~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006633 - fatty acid biosynthetic process
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 559
Rn

1 270
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Ce
+ Ce
+ At
+ At
+ At
+ At
+ Sp
+ At
+ At
+ Sc
+ Zm
+ Sc
+ At
+ At
+ At

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024