HitPredict

Interactor 1: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	19013454, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PC_rep~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 363 Hs			1 908
+	Hs
		872262 RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Rn
		1116239 RD23B_RAT (3-363): 6.38e-109: 326: 52.05		PSMD2_RAT (1-908): 0: 1272: 98.57
+	Hs
		1027821 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027815 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027806 UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	At
		1195577 RD23C_ARATH (3-363): 1.8e-100: 305: 33.25		PSD2A_ARATH (11-906): 0: 1080: 49.51
+	Hs
		923974 RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Sp
		251964 RHP23_SCHPO (3-363): 2.02e-78: 247: 33.25		RPN1_SCHPO (8-905): 0: 1025: 47.67
+	Dm
		1362832 Q9VCD5_DROME (3-362): 3.96e-58: 191: 27.90		Q9VW54_DROME (3-906): 0: 1063: 60.65
+	Hs
		872202 RD23A_HUMAN (1-363): 4.01e-119: 350: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Rn
		292215 RD23B_RAT (3-363): 6.38e-109: 326: 52.05		PSMD1_RAT (59-845): 0: 784: 17.42
+	Hs
		872303 RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Sc
		697080 RAD23_YEAST (3-361): 1e-75: 240: 28.57		RPN1_YEAST (49-906): 0: 869: 37.71
+	Sc
		753873 DSK2_YEAST (1-246): 3.36e-35: 134: 20.65		RPN1_YEAST (49-906): 0: 869: 37.71
+	Hs
		1303954 UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		1303948 UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		1303937 UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Sc
		693266 RAD23_YEAST (3-361): 1e-75: 240: 28.57		RPN2_YEAST (59-841): 0: 679: 17.83
+	Hs
		924124 RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47		PSMD1_HUMAN (59-845): 0: 790: 17.31