HitPredict

Interactor 1: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	32296183, 33277362, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, validated two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UBA~UBA, UBA~ubiquitin, ubiquitin~ubiquitin, UBA~XPC-binding
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0031593 - polyubiquitin modification-dependent protein binding GO:0032434 - regulation of proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 409 Hs			1 624
+	Hs
		872226 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		872229 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		872222 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		1355403 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1357342 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1345051 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		872275 RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		872137 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		803807 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		872136 RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Sp
		251965 RHP23_SCHPO (1-409): 1.78e-77: 245: 34.43		DSK2_SCHPO (33-240): 1.27e-27: 116: 23.26
+	Sc
		697098 RAD23_YEAST (1-407): 2.12e-72: 233: 28.41		DSK2_YEAST (32-239): 1.13e-31: 128: 31.19
+	Zm
		80385 B6TNT9_MAIZE (2-406): 5.59e-58: 199: 14.18		K7UR93_MAIZE (33-313): 1.02e-39: 152: 14.39
+	Dm
		547941 Q9V3W9_DROME (1-408): 5.38e-89: 277: 36.75		RS27A_DROME (33-103): 6.99e-13: 68.4: 33.33
+	Hs
		924435 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Dm
		1362834 Q9VXF9_DROME (1-406): 8.36e-58: 197: 15.39		Q9VCD5_DROME (33-258): 3.37e-32: 127: 15.58
+	Hs
		1174926 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		TMUB2_HUMAN (6-143): 8.33e-26: 110: 25.00
+	Hs
		924216 UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Ce
		107538 UBQL_CAEEL (1-404): 1.91e-58: 200: 14.68		RL40_CAEEL (33-103): 7.5e-13: 67.7: 33.33
+	Dm
		547961 Q9VXF9_DROME (1-406): 8.36e-58: 197: 15.39		RS27A_DROME (33-103): 6.99e-13: 68.4: 33.33