HitPredict

Interactor 1: EPHB4 (P54760)
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
Gene: EPHB4

Interactor 2: TMPS3 (P57727)
Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein)
Gene: TMPRSS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 987 Hs			1 454
+	Hs
		872570 EPHB4_HUMAN (1-987): 0: 1122: 100.00		TMPSD_HUMAN (53-449): 2.32e-113: 347: 37.04
+	Hs
		872605 EPHB4_HUMAN (1-987): 0: 1122: 100.00		ST14_HUMAN (72-449): 4.39e-108: 340: 29.23
+	Hs
		872582 EPHB4_HUMAN (1-987): 0: 1122: 100.00		TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16
+	Hs
		1072608 EPHA7_HUMAN (3-981): 0: 1100: 48.64		TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16
+	Hs
		872716 EPHA4_HUMAN (3-981): 0: 1093: 49.70		TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16
+	Hs
		1072534 EPHA7_HUMAN (3-981): 0: 1100: 48.64		TM11B_HUMAN (43-449): 2.39e-107: 325: 27.49
+	Hs
		409508 EPHB4_HUMAN (1-987): 0: 1122: 100.00		HEPS_HUMAN (119-449): 2.21e-98: 303: 37.43
+	Hs
		428666 EPHA3_HUMAN (13-975): 0: 1080: 48.35		TRY1_HUMAN (207-452): 5.08e-94: 285: 34.27
+	Hs
		428664 EPHA1_HUMAN (11-969): 0: 944: 40.17		TRY1_HUMAN (207-452): 5.08e-94: 285: 34.27
+	Hs
		177785 INSR_HUMAN (380-879): 9.63e-136: 443: 29.65		TMPS2_HUMAN (27-451): 6.62e-117: 353: 40.19
+	Hs
		177792 IGF1R_HUMAN (390-876): 1.79e-133: 437: 28.00		TMPS2_HUMAN (27-451): 6.62e-117: 353: 40.19
+	Hs
		411506 INSR_HUMAN (380-879): 9.63e-136: 443: 29.65		TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16
+	Hs
		435776 IGF1R_HUMAN (390-876): 1.79e-133: 437: 28.00		TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16
+	Hs
		411419 INSR_HUMAN (380-879): 9.63e-136: 443: 29.65		TM11B_HUMAN (43-449): 2.39e-107: 325: 27.49
+	Hs
		435683 IGF1R_HUMAN (390-876): 1.79e-133: 437: 28.00		TM11B_HUMAN (43-449): 2.39e-107: 325: 27.49
+	Rn
		544821 INSR_RAT (380-879): 6.3e-136: 444: 30.43		PLMN_RAT (101-451): 3.28e-96: 308: 30.56
+	Rn
		94086 INSR_RAT (380-879): 6.3e-136: 444: 30.43		F1LS97_RAT (102-449): 1.67e-99: 305: 37.40