HitPredict

Interactor 1: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	30833792, 35271311, 10683148, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~SNARE
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0019905 - syntaxin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 295 Hs			1 236
+	Hs
		235158 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Hs
		212779 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		212995 SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Zm
		39691 A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80		A0A1D6N0J7_MAIZE (2-235): 2.57e-63: 200: 18.01
+	Dm
		1095586 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		320285 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		320411 SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169421 SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Hs
		169605 SNAB_HUMAN (1-292): 6.03e-113: 329: 84.25		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		1095557 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		Q5BI25_DROME (12-138): 1.55e-15: 76.4: 12.21
+	Sc
		696591 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		TLG1_YEAST (2-220): 3.95e-32: 118: 15.07
+	Hs
		235208 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Dm
		1095587 SNAP_DROME (5-295): 7.84e-105: 308: 61.51		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	Hs
		1306217 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	Sc
		696560 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		VAM7_YEAST (46-211): 1.29e-25: 103: 21.56
+	Sc
		611768 SEC17_YEAST (8-294): 4.63e-88: 266: 34.48		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Hs
		212982 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Dm
		1353750 Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Hs
		320397 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169588 SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61