HitPredict

Interactor 1: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Interactor 2: DDI2 (Q5TDH0)
Protein DDI1 homolog 2 (EC 3.4.23.-)
Gene: DDI2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27114451
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	UIM~ubiquitin, VWA_2~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 399
+	Hs
		874144 PSMD4_HUMAN (1-364): 0: 530: 100.00		DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75
+	Dm
		874047 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VXF9_DROME (5-395): 2.61e-124: 368: 46.38
+	Hs
		874198 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		874195 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20
+	Hs
		874185 PSMD4_HUMAN (1-364): 0: 530: 100.00		UBQL4_HUMAN (8-241): 1.8e-44: 164: 14.59
+	Xl
		1118797 Q4V845_XENLA (1-364): 0: 519: 91.48		Q9PVN8_XENLA (31-241): 2.49e-40: 152: 14.46
+	Hs
		803454 PSMD4_HUMAN (1-364): 0: 530: 100.00		BAG6_HUMAN (4-173): 4.8e-28: 118: 15.08
+	Hs
		872125 PSMD4_HUMAN (1-364): 0: 530: 100.00		RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00
+	Xl
		1118798 Q4V845_XENLA (1-364): 0: 519: 91.48		BAG6A_XENLA (4-226): 1e-26: 114: 13.90
+	Hs
		874068 PSMD4_HUMAN (1-364): 0: 530: 100.00		RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06
+	Dm
		874046 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VWD9_DROME (5-241): 8.99e-44: 161: 16.39
+	At
		874024 PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32		DSK2B_ARATH (4-241): 1.39e-53: 188: 19.76
+	Sc
		756936 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		DDI1_YEAST (3-395): 7.99e-93: 287: 30.92
+	Dm
		874036 PSMD4_DROME (1-359): 6.74e-149: 428: 57.40		Q9VCD5_DROME (5-227): 2.18e-35: 133: 12.88
+	Sc
		756974 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		DSK2_YEAST (19-213): 6.83e-31: 123: 15.49
+	Sc
		697082 RPN10_YEAST (1-224): 1.27e-98: 295: 49.15		RAD23_YEAST (5-202): 3.88e-26: 110: 16.00