Protein: BLK
Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)

Gene: BLK
Organism: Homo sapiens
Interactions: 194
UniProt ID: P51451

Gene Ontology (top 5):
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005102 - signaling receptor binding
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

199508

EFS
Embryonal Fyn-associated substrate

5

20

High-throughput

0.930

High

776611

STAT3
Signal transducer and activator of transcription 3

5

15

High-throughput

0.925

High

338144

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.924

High

147406

SOCS3
Suppressor of cytokine signaling 3

2

19

High-throughput

0.783

High

155835

SH21B
SH2 domain-containing protein 1B

2

20

High-throughput

0.783

High

655277

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

High-throughput

0.783

High

802808

CRKL
Crk-like protein

2

20

High-throughput

0.783

High

846465

SLAP1
Src-like-adapter

2

18

High-throughput

0.783

High

846466

GRB10
Growth factor receptor-bound protein 10

2

18

High-throughput

0.783

High

846469

BIRC2
Baculoviral IAP repeat-containing protein 2

2

6

High-throughput

0.783

High

846504

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.783

High

383699

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

846470

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

2

7

High-throughput

0.776

High

414828

CDK1
Cyclin-dependent kinase 1

2

13

High-throughput

0.737

High

846495

CCD33
Coiled-coil domain-containing protein 33

3

3

High-throughput

0.733

High

846484

ANR54
Ankyrin repeat domain-containing protein 54

2

15

High-throughput

0.726

High

441471

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

499249

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

846468

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

118710

AIP
AH receptor-interacting protein

1

13

High-throughput

0.691

High

179930

TLR3
Toll-like receptor 3

1

13

High-throughput

0.691

High

237481

TLR2
Toll-like receptor 2

1

12

High-throughput

0.691

High

411648

LCK
Tyrosine-protein kinase Lck

1

19

High-throughput

0.691

High

433653

LYN
Tyrosine-protein kinase Lyn

1

19

High-throughput

0.691

High

821944

KC1A
Casein kinase I isoform alpha

1

6

High-throughput

0.691

High

846447

IRAK1
Interleukin-1 receptor-associated kinase 1

1

3

High-throughput

0.691

High

846467

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

12

High-throughput

0.691

High

431666

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.683

High

438007

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.683

High

397850

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.665

High

415266

ATPB
ATP synthase subunit beta, mitochondrial

3

4

High-throughput

0.650

High

846474

CDC37
Hsp90 co-chaperone Cdc37

3

14

High-throughput

0.650

High

181824

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.647

High

562634

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

17

Small-scale

0.647

High

601856

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

738179

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.647

High

846473

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

846532

F217B
Protein FAM217B

3

0

High-throughput

0.638

High

269523

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.621

High

846486

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

2

High-throughput

0.618

High

846488

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

2

High-throughput

0.618

High

846497

LRTM2
Leucine-rich repeat and transmembrane domain-containing protein 2

1

3

High-throughput

0.618

High

846446

BLK
Tyrosine-protein kinase Blk

1

18

High-throughput

0.618

High

240475

CYTIP
Cytohesin-interacting protein

2

20

High-throughput

0.611

High

846479

GLYR1
Cytokine-like nuclear factor N-PAC

2

1

High-throughput

0.611

High

252970

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

823358

PAXI
Paxillin

2

20

High-throughput

0.606

High

843580

FXR1
RNA-binding protein FXR1

2

5

High-throughput

0.606

High

843988

FXR2
RNA-binding protein FXR2

2

5

High-throughput

0.606

High

846531

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

846537

STAP2
Signal-transducing adaptor protein 2

2

4

High-throughput

0.606

High

846541

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

15

High-throughput

0.606

High

846544

IKZF3
Zinc finger protein Aiolos

2

7

High-throughput

0.606

High

521091

ECP
Eosinophil cationic protein

2

0

High-throughput

0.602

High

846499

BANK1
B-cell scaffold protein with ankyrin repeats

2

4

Small-scale

0.601

High

443403

VIME
Vimentin

2

8

High-throughput

0.594

High

623227

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

2

2

High-throughput

0.574

High

388315

HSPB1
Heat shock protein beta-1

2

7

High-throughput

0.571

High

423180

PDIA1
Protein disulfide-isomerase

2

6

High-throughput

0.571

High

428098

TBB5
Tubulin beta chain

2

8

High-throughput

0.571

High

432610

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

13

High-throughput

0.571

High

455236

PARP1
Poly [ADP-ribose] polymerase 1

2

8

High-throughput

0.571

High

501845

BIP
Endoplasmic reticulum chaperone BiP

2

20

High-throughput

0.571

High

751543

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

846459

DSG1
Desmoglein-1

2

10

High-throughput

0.571

High

157120

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

2

3

High-throughput

0.558

High

616625

GLRA2
Glycine receptor subunit alpha-2

2

2

High-throughput

0.558

High

70970

ZBT42
Zinc finger and BTB domain-containing protein 42

2

3

High-throughput

0.553

High

846483

ZN774
Zinc finger protein 774

2

4

High-throughput

0.553

High

846508

ZBT8A
Zinc finger and BTB domain-containing protein 8A

2

9

High-throughput

0.553

High

846513

JKIP1
Janus kinase and microtubule-interacting protein 1

2

15

High-throughput

0.553

High

846515

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

2

3

High-throughput

0.553

High

846523

SSBP3
Single-stranded DNA-binding protein 3

2

2

High-throughput

0.553

High

487245

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

61333

CNOT1
CCR4-NOT transcription complex subunit 1

1

1

High-throughput

0.536

High

201578

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

4

High-throughput

0.536

High

239089

CTND1
Catenin delta-1

1

17

High-throughput

0.536

High

317934

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

9

High-throughput

0.536

High

319407

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

1

1

High-throughput

0.536

High

381871

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.536

High

531084

EF2
Elongation factor 2

1

5

High-throughput

0.536

High

538159

ENPL
Endoplasmin

1

20

High-throughput

0.536

High

602822

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.536

High

636857

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

724720

MYH9
Myosin-9

1

5

High-throughput

0.536

High

770750

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

814618

CDX1
Homeobox protein CDX-1

1

6

High-throughput

0.536

High

821128

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

826575

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

842788

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

843115

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

846458

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

846475

CCL15
C-C motif chemokine 15

1

2

High-throughput

0.536

High

846478

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

1

High-throughput

0.536

High

846485

FXL22
F-box and leucine-rich protein 22

1

1

High-throughput

0.536

High

846494

TAGAP
T-cell activation Rho GTPase-activating protein

1

17

High-throughput

0.536

High

846514

RBM14
RNA-binding protein 14

1

8

High-throughput

0.536

High

846519

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

846529

CNO10
CCR4-NOT transcription complex subunit 10

1

2

High-throughput

0.536

High

846538

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

8

High-throughput

0.536

High

846542

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.536

High

241284

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

12

High-throughput

0.521

High

846510

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

2

High-throughput

0.521

High

610303

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.515

High

563040

YBOX3
Y-box-binding protein 3

1

0

High-throughput

0.513

High

846453

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.513

High

846454

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.513

High

846487

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.513

High

846489

ABCA9
ATP-binding cassette sub-family A member 9

1

0

High-throughput

0.513

High

846507

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.513

High

846509

FBX17
F-box only protein 17

1

0

High-throughput

0.513

High

846526

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.513

High

846540

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.513

High

846543

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.513

High

489388

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.501

High

846460

UBE3A
Ubiquitin-protein ligase E3A

1

16

Small-scale

0.501

High

846462

B2CL1
Bcl-2-like protein 1

1

3

Small-scale

0.501

High

846548

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

259203

CAD16
Cadherin-16

1

12

High-throughput

0.489

High

264191

CDC45
Cell division control protein 45 homolog

1

2

High-throughput

0.489

High

270004

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.489

High

674007

V2R
Vasopressin V2 receptor

1

9

High-throughput

0.489

High

846452

CXCR4
C-X-C chemokine receptor type 4

1

7

High-throughput

0.489

High

846455

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

3

High-throughput

0.489

High

846457

CTG1B
Cancer/testis antigen 1

1

1

High-throughput

0.489

High

846476

RTN1
Reticulon-1

1

4

High-throughput

0.489

High

846491

DJC10
DnaJ homolog subfamily C member 10

1

6

High-throughput

0.489

High

846502

BBX
HMG box transcription factor BBX

1

4

High-throughput

0.489

High

846503

NICA
Nicastrin

1

2

High-throughput

0.489

High

846505

AP3S1
AP-3 complex subunit sigma-1

1

4

High-throughput

0.489

High

846512

ARL5B
ADP-ribosylation factor-like protein 5B

1

4

High-throughput

0.489

High

846516

MYCT
Proton myo-inositol cotransporter

1

1

High-throughput

0.489

High

846517

DCE1
Glutamate decarboxylase 1

1

5

High-throughput

0.489

High

846518

PHB2
Prohibitin-2

1

1

High-throughput

0.489

High

846524

YTHD1
YTH domain-containing family protein 1

1

5

High-throughput

0.489

High

846525

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

4

High-throughput

0.489

High

846527

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.489

High

846536

GBG12

1

3

High-throughput

0.489

High

64203

UBP27
Ubiquitin carboxyl-terminal hydrolase 27

1

3

High-throughput

0.479

High

303029

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

516006

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

2

Small-scale

0.479

High

771174

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

2

Small-scale

0.479

High

846463

TRAF3
TNF receptor-associated factor 3

1

18

Small-scale

0.479

High

846480

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

846492

TRM2A
tRNA

1

1

High-throughput

0.479

High

2752

A0A0C4DGF1
Zinc finger and BTB domain containing 32

1

1

High-throughput

0.470

High

846481

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

846482

ZMAT1
Zinc finger matrin-type protein 1

1

1

High-throughput

0.439

High

846547

ZBT32
Zinc finger and BTB domain-containing protein 32

1

2

High-throughput

0.439

High

262401

TULP3
Tubby-related protein 3

1

6

High-throughput

0.437

High

575341

EGR1
Early growth response protein 1

1

3

High-throughput

0.437

High

846496

VA0D2
V-type proton ATPase subunit d 2

1

1

High-throughput

0.437

High

846546

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

3

High-throughput

0.437

High

815957

ATPO
ATP synthase subunit O, mitochondrial

2

0

High-throughput

0.328

High

846493

SYCP3
Synaptonemal complex protein 3

2

0

High-throughput

0.319

High

846545

A4GCT
Alpha-1,4-N-acetylglucosaminyltransferase

2

0

High-throughput

0.318

High

316313

TYDP2
Tyrosyl-DNA phosphodiesterase 2

2

0

High-throughput

0.316

High

846534

GAR1
H/ACA ribonucleoprotein complex subunit 1

2

0

High-throughput

0.298

High

212209

ERD23
ER lumen protein-retaining receptor 3

1

0

High-throughput

0.279

Low

279102

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.279

Low

279931

ATP5L
ATP synthase subunit g, mitochondrial

1

0

High-throughput

0.279

Low

321983

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

361686

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

514324

UTER
Uteroglobin

1

0

High-throughput

0.279

Low

548159

KCNE1
Potassium voltage-gated channel subfamily E member 1

1

0

High-throughput

0.279

Low

579513

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.279

Low

671051

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.279

Low

735893

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

846448

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.279

Low

846449

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.279

Low

846450

ATP5I
ATP synthase subunit e, mitochondrial

1

0

High-throughput

0.279

Low

846451

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.279

Low

846456

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.279

Low

846464

CHIT1
Chitotriosidase-1

1

0

High-throughput

0.279

Low

846471

BTG3
Protein BTG3

1

0

High-throughput

0.279

Low

846477

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

846498

CO053
Putative uncharacterized protein encoded by LINC02694

1

0

High-throughput

0.279

Low

846500

OR5C1
Olfactory receptor 5C1

1

0

High-throughput

0.279

Low

846501

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.279

Low

846506

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.279

Low

846511

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

0

High-throughput

0.279

Low

846520

EFC11
EF-hand calcium-binding domain-containing protein 11

1

0

High-throughput

0.279

Low

846521

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.279

Low

846522

CINP
Cyclin-dependent kinase 2-interacting protein

1

0

High-throughput

0.279

Low

846528

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.279

Low

846533

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.279

Low

846539

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.279

Low

846461

MBTD1
MBT domain-containing protein 1

1

0

High-throughput

0.269

Low

846490

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.269

Low

846535

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.269

Low

846472

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

846549

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.249

Low

846530

XAGE1
X antigen family member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024