HitPredict

Interactor 1: NR1H2 (P55055)
Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor)
Gene: NR1H2

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 460 Hs			1 768
+	Hs
		659714 RXRB_HUMAN (36-458): 1.66e-109: 335: 23.11		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		369559 ESR1_HUMAN (3-459): 2.92e-103: 321: 21.06		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		509948 VDR_HUMAN (53-459): 5.31e-101: 310: 27.17		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		622792 COT2_HUMAN (5-456): 1.86e-100: 308: 24.45		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		369560 ESR1_HUMAN (3-459): 2.92e-103: 321: 21.06		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		818874 RXRG_HUMAN (5-457): 4.96e-117: 352: 23.25		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041596 NR1D2_HUMAN (86-176): 1.82e-16: 84: 43.96		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		369558 ESR1_HUMAN (3-459): 2.92e-103: 321: 21.06		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Dm
		709190 ECR_DROME (33-459): 7.81e-98: 314: 34.96		Q9V9R2_DROME (30-768): 0: 612: 24.52
+	Hs
		500418 THA_HUMAN (64-423): 2.01e-42: 158: 30.95		CUL1_HUMAN (18-768): 0: 707: 30.57