Protein: PTN23
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)

Gene: PTN23, PTPN23
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q9H3S7

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005768 - endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987935

GRB2
Growth factor receptor-bound protein 2

6

20

Small-scale

0.952

High

292868

GRAP2
GRB2-related adapter protein 2

4

20

Small-scale

0.905

High

1051055

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.757

High

363849

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

1357000

PDC6I
Programmed cell death 6-interacting protein

2

7

Small-scale

0.754

High

1432897

CHM4B
Charged multivesicular body protein 4b

4

11

Small-scale

0.706

High

296567

STAM2
Signal transducing adapter molecule 2

4

20

Small-scale

0.698

High

508617

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

8

Small-scale

0.683

High

1026222

CLH1
Clathrin heavy chain 1

3

2

Small-scale

0.671

High

1432905

UBAP1
Ubiquitin-associated protein 1

4

0

Small-scale

0.664

High

483209

CLCA
Clathrin light chain A

3

1

Small-scale

0.662

High

1277474

ZFY16
Zinc finger FYVE domain-containing protein 16

3

7

Small-scale

0.662

High

483393

CLCB
Clathrin light chain B

3

1

Small-scale

0.656

High

169748

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

12

Small-scale

0.650

High

1407461

TS101
Tumor susceptibility gene 101 protein

2

4

Small-scale

0.631

High

139411

VMA5A
von Willebrand factor A domain-containing protein 5A

2

2

High-throughput

0.628

High

1277407

NT2NA
Notch homolog 2 N-terminal-like protein A

2

5

High-throughput

0.628

High

1391174

BICD1
Protein bicaudal D homolog 1

2

7

High-throughput

0.624

High

187406

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

Small-scale

0.618

High

412605

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

557470

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

1255519

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

731613

STIP1
Stress-induced-phosphoprotein 1

2

6

High-throughput

0.611

High

1065027

FGL1
Fibrinogen-like protein 1

3

6

High-throughput

0.609

High

347320

BAG2
BAG family molecular chaperone regulator 2

2

1

High-throughput

0.601

High

552695

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.586

High

935126

TERA
Transitional endoplasmic reticulum ATPase

2

9

High-throughput

0.584

High

1368300

STAM1
Signal transducing adapter molecule 1

2

20

Small-scale

0.584

High

1432908

ANFY1
Rabankyrin-5

2

4

Small-scale

0.584

High

1397108

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

944163

WDR4
tRNA

1

4

Small-scale

0.578

High

1432901

SH24A
SH2 domain-containing protein 4A

1

20

High-throughput

0.575

High

1408393

SH3G2
Endophilin-A1

1

20

Small-scale

0.573

High

572211

TRI27
Zinc finger protein RFP

1

4

High-throughput

0.573

High

681514

PSA3
Proteasome subunit alpha type-3

1

6

High-throughput

0.573

High

1198522

CEP55
Centrosomal protein of 55 kDa

1

2

High-throughput

0.573

High

331322

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.536

High

359738

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.536

High

408163

TBB4A
Tubulin beta-4A chain

1

5

High-throughput

0.536

High

417753

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.536

High

648230

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.536

High

698027

CALR
Calreticulin

1

10

High-throughput

0.536

High

761873

HSP74
Heat shock 70 kDa protein 4

1

9

High-throughput

0.536

High

827260

ARL1
ADP-ribosylation factor-like protein 1

1

8

High-throughput

0.536

High

931109

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.536

High

1129882

EPN4
Clathrin interactor 1

1

1

High-throughput

0.536

High

1181430

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

1365232

HS105
Heat shock protein 105 kDa

1

9

High-throughput

0.536

High

1417876

DUS16
Dual specificity protein phosphatase 16

1

7

High-throughput

0.536

High

1431830

SLK
STE20-like serine/threonine-protein kinase

1

14

High-throughput

0.536

High

570979

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

697656

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.513

High

761028

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.513

High

1414160

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1432912

SNX12
Sorting nexin-12

1

0

High-throughput

0.513

High

276520

PDCD6
Programmed cell death protein 6

1

6

Small-scale

0.506

High

1432900

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

Small-scale

0.504

High

1315991

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

1432906

HPBP1
Hsp70-binding protein 1

1

3

High-throughput

0.489

High

1209652

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

Small-scale

0.481

High

67707

RHG32
Rho GTPase-activating protein 32

1

5

Small-scale

0.479

High

135995

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

3

Small-scale

0.479

High

175204

SC16A
Protein transport protein Sec16A

1

1

Small-scale

0.479

High

218768

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

226203

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

242912

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

256507

TOM1
Target of Myb1 membrane trafficking protein

1

7

Small-scale

0.479

High

336134

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

8

Small-scale

0.479

High

344791

AP2A1
AP-2 complex subunit alpha-1

1

3

Small-scale

0.479

High

373136

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

565473

ITA4
Integrin alpha-4

1

12

High-throughput

0.479

High

589671

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

613459

VINC
Vinculin

1

1

High-throughput

0.479

High

630970

RAB4A
Ras-related protein Rab-4A

1

7

High-throughput

0.479

High

631473

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.479

High

655926

TBG1
Tubulin gamma-1 chain

1

10

High-throughput

0.479

High

696489

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

703705

MK01
Mitogen-activated protein kinase 1

1

12

High-throughput

0.479

High

717996

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.479

High

761513

HS71L
Heat shock 70 kDa protein 1-like

1

8

High-throughput

0.479

High

769162

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

791723

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

828251

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

Small-scale

0.479

High

831419

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

839823

EPS15
Epidermal growth factor receptor substrate 15

1

18

Small-scale

0.479

High

878558

PAXI
Paxillin

1

10

High-throughput

0.479

High

881808

DHYS
Deoxyhypusine synthase

1

1

Small-scale

0.479

High

896635

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

902068

RAB9A
Ras-related protein Rab-9A

1

9

High-throughput

0.479

High

907579

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

912807

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

3

Small-scale

0.479

High

942882

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

8

High-throughput

0.479

High

971075

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

986719

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

987212

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

Small-scale

0.479

High

989116

AP2B1
AP-2 complex subunit beta

1

2

Small-scale

0.479

High

1026541

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1041283

CAV1
Caveolin-1

1

6

High-throughput

0.479

High

1045764

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

1100373

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

1138053

TNIP1
TNFAIP3-interacting protein 1

1

8

Small-scale

0.479

High

1141931

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1144876

RABE1
Rab GTPase-binding effector protein 1

1

1

Small-scale

0.479

High

1154169

ITSN1
Intersectin-1

1

17

Small-scale

0.479

High

1156209

ZYX
Zyxin

1

10

High-throughput

0.479

High

1205170

SH319
SH3 domain-containing protein 19

1

20

Small-scale

0.479

High

1233480

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1251268

DNMBP
Dynamin-binding protein

1

19

Small-scale

0.479

High

1256904

TM1L2
TOM1-like protein 2

1

7

Small-scale

0.479

High

1289623

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1350184

ALMS1
Centrosome-associated protein ALMS1

1

1

Small-scale

0.479

High

1350449

BICD2
Protein bicaudal D homolog 2

1

6

High-throughput

0.479

High

1402166

KS6C1
Ribosomal protein S6 kinase delta-1

1

7

Small-scale

0.479

High

1410592

TBA1C
Tubulin alpha-1C chain

1

4

Small-scale

0.479

High

1420646

LRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

1

2

High-throughput

0.479

High

1428968

WWTR1
WW domain-containing transcription regulator protein 1

1

12

High-throughput

0.479

High

1429838

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1432898

WNK1
Serine/threonine-protein kinase WNK1

1

10

Small-scale

0.479

High

1432899

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.479

High

1432903

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

5

Small-scale

0.479

High

1432909

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1432910

TBK1
Serine/threonine-protein kinase TBK1

1

15

Small-scale

0.479

High

1432914

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

Small-scale

0.479

High

547691

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

Small-scale

0.458

High

1107608

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

Small-scale

0.458

High

1350949

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

Small-scale

0.458

High

1356322

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

1385694

ENTR1
Endosome-associated-trafficking regulator 1

1

0

Small-scale

0.458

High

1432911

RABX5
Rab5 GDP/GTP exchange factor

1

0

Small-scale

0.458

High

1432913

SYNRG
Synergin gamma

1

0

Small-scale

0.458

High

1428536

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.457

High

330315

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.445

High

537901

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.445

High

619926

VCAM1
Vascular cell adhesion protein 1

1

14

High-throughput

0.445

High

845135

EAA3
Excitatory amino acid transporter 3

1

6

High-throughput

0.445

High

1315714

DND1
Dead end protein homolog 1

1

3

High-throughput

0.445

High

1352572

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

6

High-throughput

0.445

High

1367263

ESR2
Estrogen receptor beta

1

9

High-throughput

0.445

High

1432902

ITM2C
Integral membrane protein 2C

1

3

High-throughput

0.445

High

1432904

DDX28
Probable ATP-dependent RNA helicase DDX28

1

3

High-throughput

0.445

High

106646

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

130239

PGRC1
Membrane-associated progesterone receptor component 1

1

5

Small-scale

0.437

High

560520

IFM1
Interferon-induced transmembrane protein 1

1

4

High-throughput

0.437

High

643066

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.437

High

1031542

IFM3
Interferon-induced transmembrane protein 3

1

4

High-throughput

0.437

High

1416678

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

1432915

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

1104099

RM49
Large ribosomal subunit protein mL49

1

3

High-throughput

0.407

High

1328582

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

1412285

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.279

Low

1432907

RELCH
RAB11-binding protein RELCH

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025