Protein: PDC6I
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)

Gene: PDC6I, PDCD6IP
Organism: Homo sapiens
Interactions: 238
UniProt ID: Q8WUM4

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000915 - actomyosin contractile ring assembly
GO:0001772 - immunological synapse
GO:0005768 - endosome
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356959

PDC6I
Programmed cell death 6-interacting protein

6

16

Small-scale

0.931

High

1198471

CEP55
Centrosomal protein of 55 kDa

10

5

Small-scale

0.761

High

1357001

CHM4B
Charged multivesicular body protein 4b

12

19

Small-scale

0.759

High

1356983

TS101
Tumor susceptibility gene 101 protein

12

6

Small-scale

0.758

High

276494

PDCD6
Programmed cell death protein 6

8

13

Small-scale

0.757

High

1357000

PTN23
Tyrosine-protein phosphatase non-receptor type 23

2

7

Small-scale

0.754

High

1356973

SH3K1
SH3 domain-containing kinase-binding protein 1

8

20

Small-scale

0.752

High

1356990

CHM4A
Charged multivesicular body protein 4a

6

19

Small-scale

0.733

High

363621

EGFR
Epidermal growth factor receptor

6

12

Small-scale

0.729

High

1357005

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

5

1

Small-scale

0.712

High

508336

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

14

Small-scale

0.708

High

557401

SRC
Proto-oncogene tyrosine-protein kinase Src

3

17

Small-scale

0.678

High

1356984

SH3G1
Endophilin-A2

4

20

Small-scale

0.674

High

1356974

CHM4C
Charged multivesicular body protein 4c

3

19

Small-scale

0.658

High

1356985

SH3G2
Endophilin-A1

3

20

Small-scale

0.658

High

1357030

CD2AP
CD2-associated protein

3

20

Small-scale

0.647

High

1356991

ACE2
Angiotensin-converting enzyme 2

3

4

Small-scale

0.640

High

473450

HCK
Tyrosine-protein kinase HCK

2

17

Small-scale

0.636

High

609758

LEG3
Galectin-3

2

8

Small-scale

0.631

High

908146

KS6A3
Ribosomal protein S6 kinase alpha-3

2

12

High-throughput

0.628

High

987797

GRB2
Growth factor receptor-bound protein 2

2

20

High-throughput

0.613

High

1357031

SAR1B
Small COPII coat GTPase SAR1B

2

3

High-throughput

0.611

High

669395

PAR1
Proteinase-activated receptor 1

3

2

Small-scale

0.606

High

1357022

TTF2
Transcription termination factor 2

2

17

Small-scale

0.600

High

132182

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

10

Small-scale

0.595

High

440648

FYN
Tyrosine-protein kinase Fyn

1

17

Small-scale

0.594

High

1356976

SGSM3
Small G protein signaling modulator 3

2

0

Small-scale

0.593

High

1339628

TNIP2
TNFAIP3-interacting protein 2

2

4

High-throughput

0.586

High

242401

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.584

High

1051028

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.584

High

1125289

FAK2
Protein-tyrosine kinase 2-beta

2

19

Small-scale

0.584

High

1280035

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

Small-scale

0.578

High

140379

SDCB1
Syntenin-1

1

6

Small-scale

0.573

High

619868

VCAM1
Vascular cell adhesion protein 1

2

8

High-throughput

0.571

High

934908

TERA
Transitional endoplasmic reticulum ATPase

2

5

High-throughput

0.571

High

428193

RLA1
Large ribosomal subunit protein P1

2

0

High-throughput

0.559

High

1155583

EZH2
Histone-lysine N-methyltransferase EZH2

2

8

High-throughput

0.549

High

1121477

KEAP1
Kelch-like ECH-associated protein 1

1

6

High-throughput

0.541

High

361314

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

467699

CEL2A
Chymotrypsin-like elastase family member 2A

1

5

High-throughput

0.536

High

691803

MK03
Mitogen-activated protein kinase 3

1

7

High-throughput

0.536

High

703662

MK01
Mitogen-activated protein kinase 1

1

7

High-throughput

0.536

High

773940

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

788117

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

854188

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

966668

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

1049606

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1113829

CUL3
Cullin-3

1

11

High-throughput

0.536

High

1115849

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

19

High-throughput

0.536

High

1146441

KS6A2
Ribosomal protein S6 kinase alpha-2

1

12

High-throughput

0.536

High

1293379

CARM1
Histone-arginine methyltransferase CARM1

1

8

High-throughput

0.536

High

1322763

CNTRB
Centrobin

1

17

High-throughput

0.536

High

1326008

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.536

High

1353019

GEMI5
Gem-associated protein 5

1

10

High-throughput

0.536

High

1356966

TFG
Protein TFG

1

8

High-throughput

0.536

High

1356994

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

2

High-throughput

0.536

High

1357002

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

6

High-throughput

0.536

High

1357012

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.536

High

372678

MYC
Myc proto-oncogene protein

2

19

High-throughput

0.533

High

1327827

ARRD1
Arrestin domain-containing protein 1

1

7

Small-scale

0.527

High

771639

DRD3
D(3) dopamine receptor

1

4

Small-scale

0.523

High

463176

YES
Tyrosine-protein kinase Yes

1

18

Small-scale

0.515

High

1357032

STK24
Serine/threonine-protein kinase 24

1

20

High-throughput

0.515

High

178969

SCAM2
Secretory carrier-associated membrane protein 2

1

0

High-throughput

0.513

High

1356975

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

1357028

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

1161161

MK06
Mitogen-activated protein kinase 6

1

17

High-throughput

0.508

High

1357027

RNF11
RING finger protein 11

1

7

High-throughput

0.508

High

291458

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.501

High

328086

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

6

High-throughput

0.501

High

952263

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.501

High

1249940

LRRN1
Leucine-rich repeat neuronal protein 1

1

5

High-throughput

0.501

High

1356978

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

10

Small-scale

0.501

High

1356986

NEUL2
Neuralized-like protein 2

1

2

Small-scale

0.501

High

1356988

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

1

6

High-throughput

0.501

High

1356996

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

6

High-throughput

0.501

High

1356999

SDCB2
Syntenin-2

1

6

High-throughput

0.501

High

668194

CXCR1
C-X-C chemokine receptor type 1

1

3

High-throughput

0.494

High

1357025

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

471151

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.489

High

1111137

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.489

High

1356967

SYN2
Synapsin-2

1

4

High-throughput

0.489

High

1356981

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.489

High

1356982

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.489

High

1356989

TX101
Testis-expressed protein 101

1

2

High-throughput

0.489

High

1153075

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

640357

DRD1
D(1A) dopamine receptor

1

3

Small-scale

0.481

High

63238

VP37C
Vacuolar protein sorting-associated protein 37C

1

13

Small-scale

0.481

High

276914

VPS4B
Vacuolar protein sorting-associated protein 4B

1

12

Small-scale

0.481

High

791571

SYUA
Alpha-synuclein

1

4

High-throughput

0.481

High

1154143

ITSN1
Intersectin-1

1

8

High-throughput

0.481

High

1356972

ARRD3
Arrestin domain-containing protein 3

1

7

Small-scale

0.481

High

1357015

ITSN2
Intersectin-2

1

8

High-throughput

0.481

High

125541

LEG9
Galectin-9

1

7

High-throughput

0.479

High

164400

NRP1
Neuropilin-1

1

12

High-throughput

0.479

High

188948

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

346110

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

10

High-throughput

0.479

High

347835

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

378574

IL1B
Interleukin-1 beta

1

1

Small-scale

0.479

High

380103

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

404266

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

412320

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

457583

TBB5
Tubulin beta chain

1

2

Small-scale

0.479

High

484191

PGFRB
Platelet-derived growth factor receptor beta

1

6

Small-scale

0.479

High

487570

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

537594

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

560466

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

565428

ITA4
Integrin alpha-4

1

7

High-throughput

0.479

High

570522

GFAP
Glial fibrillary acidic protein

1

6

Small-scale

0.479

High

624261

TFE3
Transcription factor E3

1

14

High-throughput

0.479

High

629972

BTF3
Transcription factor BTF3

1

5

High-throughput

0.479

High

642990

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

654993

ITA6
Integrin alpha-6

1

7

High-throughput

0.479

High

655871

TBG1
Tubulin gamma-1 chain

1

7

Small-scale

0.479

High

659540

CRCM
Colorectal mutant cancer protein

1

15

High-throughput

0.479

High

693043

DPP4
Dipeptidyl peptidase 4

1

3

High-throughput

0.479

High

711920

LTK
Leukocyte tyrosine kinase receptor

1

13

High-throughput

0.479

High

731501

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

764913

CTNB1
Catenin beta-1

1

9

High-throughput

0.479

High

767279

MERL
Merlin

1

9

High-throughput

0.479

High

774522

BASI
Basigin

1

5

High-throughput

0.479

High

831126

CCNF
Cyclin-F

1

9

High-throughput

0.479

High

852651

ABCG1
ATP-binding cassette sub-family G member 1

1

1

Small-scale

0.479

High

861700

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

Small-scale

0.479

High

877461

MASP1
Mannan-binding lectin serine protease 1

1

3

Small-scale

0.479

High

883292

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

884371

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

891698

GSK3B
Glycogen synthase kinase-3 beta

1

17

High-throughput

0.479

High

904964

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

970834

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

986593

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

995717

ACTC
Actin, alpha cardiac muscle 1

1

12

Small-scale

0.479

High

1026478

HSF1
Heat shock factor protein 1

1

5

High-throughput

0.479

High

1083286

AP1B1
AP-1 complex subunit beta-1

1

11

High-throughput

0.479

High

1100921

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

1107054

BIRC3
Baculoviral IAP repeat-containing protein 3

1

11

High-throughput

0.479

High

1119857

CKAP5
Cytoskeleton-associated protein 5

1

10

High-throughput

0.479

High

1122530

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

13

High-throughput

0.479

High

1138432

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1140610

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

1143119

PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

1

2

High-throughput

0.479

High

1161571

IF16
Gamma-interferon-inducible protein 16

1

4

High-throughput

0.479

High

1259376

TBA1A
Tubulin alpha-1A chain

1

3

Small-scale

0.479

High

1277469

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

Small-scale

0.479

High

1291087

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

9

Small-scale

0.479

High

1291554

HOOK3
Protein Hook homolog 3

1

16

High-throughput

0.479

High

1324022

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.479

High

1324974

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

9

High-throughput

0.479

High

1330883

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1334690

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1339106

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1356962

SEPT1
Septin-1

1

6

High-throughput

0.479

High

1356963

TOPB1
DNA topoisomerase 2-binding protein 1

1

7

High-throughput

0.479

High

1356964

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

1356968

STAM1
Signal transducing adapter molecule 1

1

20

Small-scale

0.479

High

1356970

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

18

Small-scale

0.479

High

1356977

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

10

High-throughput

0.479

High

1356980

RUFY1
RUN and FYVE domain-containing protein 1

1

18

High-throughput

0.479

High

1356987

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1356992

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.479

High

1356993

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

6

High-throughput

0.479

High

1356995

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1356997

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

1356998

ABCG4
ATP-binding cassette sub-family G member 4

1

1

Small-scale

0.479

High

1357006

ECT2
Protein ECT2

1

11

High-throughput

0.479

High

1357007

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1357008

ANLN
Anillin

1

6

High-throughput

0.479

High

1357014

WWOX
WW domain-containing oxidoreductase

1

6

High-throughput

0.479

High

1357016

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

7

High-throughput

0.479

High

1357017

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1357018

TES
Testin

1

9

High-throughput

0.479

High

1357019

UBQL2
Ubiquilin-2

1

5

High-throughput

0.479

High

1357020

DDX20
Probable ATP-dependent RNA helicase DDX20

1

14

High-throughput

0.479

High

1357021

CLC4E
C-type lectin domain family 4 member E

1

7

High-throughput

0.479

High

567455

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

1119516

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.458

High

1258063

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.458

High

1356965

CENPI
Centromere protein I

1

0

High-throughput

0.458

High

1356969

SC5A5
Sodium/iodide cotransporter

1

0

Small-scale

0.458

High

964383

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.457

High

260920

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.457

High

564121

CFTR
Cystic fibrosis transmembrane conductance regulator

1

10

High-throughput

0.445

High

1063476

GOGA2
Golgin subfamily A member 2

1

18

High-throughput

0.445

High

1119221

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

1277278

S46A3
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3

1

1

High-throughput

0.445

High

1315694

DND1
Dead end protein homolog 1

1

6

High-throughput

0.445

High

1352565

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

4

High-throughput

0.445

High

1356960

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

1357010

ITM2C
Integral membrane protein 2C

1

7

High-throughput

0.445

High

1357024

GAB2
GRB2-associated-binding protein 2

1

6

High-throughput

0.445

High

106346

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

227623

SPOP
Speckle-type POZ protein

1

6

High-throughput

0.437

High

260210

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.437

High

277385

TP4A3
Protein tyrosine phosphatase type IVA 3

1

7

High-throughput

0.437

High

352501

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

353464

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

474149

NFIC
Nuclear factor 1 C-type

1

12

High-throughput

0.437

High

558994

LYL1
Protein lyl-1

1

8

High-throughput

0.437

High

589253

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

783353

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.437

High

799327

BRCA1
Breast cancer type 1 susceptibility protein

1

19

High-throughput

0.437

High

879301

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

14

High-throughput

0.437

High

965110

WDR5
WD repeat-containing protein 5

1

9

Small-scale

0.437

High

1031473

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.437

High

1194617

DUS28
Dual specificity phosphatase 28

1

5

High-throughput

0.437

High

1194732

FBX43
F-box only protein 43

1

1

Small-scale

0.437

High

1249054

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1254805

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1276537

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1314325

SLX4
Structure-specific endonuclease subunit SLX4

1

14

High-throughput

0.437

High

1356961

CLC4D
C-type lectin domain family 4 member D

1

6

High-throughput

0.437

High

1357003

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.437

High

1357004

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1357011

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.437

High

1357013

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1357023

TRI33
E3 ubiquitin-protein ligase TRIM33

1

17

High-throughput

0.437

High

1357026

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

1238883

MFS12
Major facilitator superfamily domain-containing protein 12

1

0

High-throughput

0.426

High

1356979

DIRC2
Solute carrier family 49 member 4

1

0

High-throughput

0.426

High

269692

PLXA2
Plexin-A2

1

3

Small-scale

0.417

High

190445

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.407

High

255137

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.407

High

261230

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330253

VENTX
Homeobox protein VENTX

1

6

High-throughput

0.407

High

955886

GMFB
Glia maturation factor beta

1

6

High-throughput

0.407

High

1007741

RAE1L
mRNA export factor RAE1

1

9

High-throughput

0.407

High

1104029

RM49
Large ribosomal subunit protein mL49

1

2

High-throughput

0.407

High

1328107

TTC9C
Tetratricopeptide repeat protein 9C

1

10

High-throughput

0.407

High

1335420

SPX3
Sugar phosphate exchanger 3

1

4

High-throughput

0.407

High

1340545

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.407

High

1357009

ZN331
Zinc finger protein 331

1

1

High-throughput

0.407

High

484598

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1137418

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.279

Low

1357029

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.269

Low

1135750

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1334275

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1356971

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025