HitPredict

Interactor 1: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Interactor 2: BIRC7 (Q96CA5)
Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]
Gene: BIRC7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11024045
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 298
+	Hs
		788221 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC7_HUMAN (1-298): 4.39e-104: 307: 100.00
+	Hs
		876964 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC6_HUMAN (54-252): 6.52e-36: 138: 21.10
+	Hs
		177663 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC5_HUMAN (78-162): 8.85e-30: 111: 32.22
+	Hs
		876944 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Hs
		876945 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Mm
		957027 CASP7_MOUSE (1-303): 3.09e-159: 447: 82.18		XIAP_MOUSE (1-96): 2.2e-12: 68.9: 18.18
+	Hs
		876939 CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Hs
		788230 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC6_HUMAN (54-252): 6.52e-36: 138: 21.10
+	Hs
		177658 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC5_HUMAN (78-162): 8.85e-30: 111: 32.22
+	Hs
		788193 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC3_HUMAN (240-298): 5.43e-20: 92: 71.67
+	Hs
		788194 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Mm
		140026 CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92		BIRC3_MOUSE (84-161): 1.59e-20: 93.5: 38.46
+	Dm
		136289 DRICE_DROME (33-302): 2.73e-108: 319: 43.02		DIAP1_DROME (77-253): 8.76e-22: 96.6: 20.23
+	Dm
		137119 CASP1_DROME (20-302): 1.17e-105: 312: 39.72		DIAP1_DROME (77-253): 8.76e-22: 96.6: 20.23
+	Hs
		788182 CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Mm
		936913 CASP3_MOUSE (57-301): 2.37e-112: 327: 55.92		XIAP_MOUSE (1-96): 2.2e-12: 68.9: 18.18
+	Dm
		136290 DRICE_DROME (33-302): 2.73e-108: 319: 43.02		DIAP2_DROME (84-207): 3.25e-11: 65.4: 24.43
+	Hs
		788252 CASP2_HUMAN (54-301): 2.1e-96: 293: 29.12		BIRC2_HUMAN (84-281): 4.95e-19: 88.9: 23.23
+	Hs
		877014 CASP6_HUMAN (56-301): 5.33e-104: 307: 38.28		XIAP_HUMAN (1-96): 3.35e-13: 71.5: 19.19
+	Rn
		1337442 Q9JHK1_RAT (53-301): 2.01e-97: 296: 31.66		XIAP_RAT (1-96): 1.08e-11: 66.9: 16.16