HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: CASPC (Q6UXS9)
Inactive caspase-12 (CASP-12)
Gene: CASP12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12097332
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CARD~CARD, Peptidase_C14~Peptidase_C14
Common GO terms	GO:0004197 - cysteine-type endopeptidase activity GO:0005737 - cytoplasm GO:0043525 - positive regulation of neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 341
+	Hs
		876968 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		CASP9_HUMAN (10-337): 1.47e-109: 327: 19.77
+	Hs
		876984 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		CASP8_HUMAN (10-338): 5.84e-106: 320: 17.24
+	Hs
		876934 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		CASP7_HUMAN (46-337): 1.88e-102: 305: 18.91
+	Hs
		788170 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		CASP3_HUMAN (52-338): 9.43e-99: 294: 23.68
+	Hs
		667430 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CASP1_HUMAN (1-341): 3.38e-126: 369: 36.92
+	Hs
		876994 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		CASPA_HUMAN (63-296): 1.63e-75: 243: 20.94
+	Hs
		788238 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		CASP2_HUMAN (40-341): 9.88e-107: 321: 22.68
+	Hs
		788254 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		CASP8_HUMAN (10-338): 5.84e-106: 320: 17.24
+	Mm
		669120 CASP2_MOUSE (1-413): 3.09e-123: 366: 28.18		CASP2_MOUSE (40-340): 3.11e-105: 317: 22.76
+	Hs
		667467 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CASP8_HUMAN (10-338): 5.84e-106: 320: 17.24
+	Hs
		788239 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		CASP7_HUMAN (46-337): 1.88e-102: 305: 18.91
+	Hs
		788156 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		CASP3_HUMAN (52-338): 9.43e-99: 294: 23.68
+	Hs
		667433 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CASP3_HUMAN (52-338): 9.43e-99: 294: 23.68
+	Hs
		788259 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		CASPA_HUMAN (63-296): 1.63e-75: 243: 20.94
+	Hs
		683049 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		CASPE_HUMAN (86-337): 6.74e-64: 204: 21.15
+	Hs
		667431 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CASPE_HUMAN (86-337): 6.74e-64: 204: 21.15
+	Hs
		667472 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CAR16_HUMAN (1-104): 2.79e-22: 94.4: 17.59
+	Rn
		796907 CASP1_RAT (7-413): 5.32e-122: 361: 24.94		CASPC_RAT (1-87): 1.59e-15: 79: 45.98
+	Hs
		667473 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CAR17_HUMAN (1-90): 6.38e-18: 80.1: 20.65
+	Hs
		667445 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		CAR18_HUMAN (1-90): 2.4e-15: 72.4: 21.74