Protein: UBE2S
Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)

Gene: UBE2S
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q16763

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1162705

APC11
Anaphase-promoting complex subunit 11

32

20

Small-scale

0.993

High

508051

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

11

20

Small-scale

0.977

High

1162668

UBE2S
Ubiquitin-conjugating enzyme E2 S

9

15

Small-scale

0.977

High

647567

UBA1
Ubiquitin-like modifier-activating enzyme 1

9

20

Small-scale

0.969

High

1162719

ANC2
Anaphase-promoting complex subunit 2

4

18

Small-scale

0.901

High

1162709

RBX2
RING-box protein 2

3

20

Small-scale

0.861

High

241821

PRKN
E3 ubiquitin-protein ligase parkin

2

20

Small-scale

0.768

High

1107407

BIRC2
Baculoviral IAP repeat-containing protein 2

2

20

Small-scale

0.767

High

822690

VHL
von Hippel-Lindau disease tumor suppressor

5

4

Small-scale

0.724

High

623364

RO52
E3 ubiquitin-protein ligase TRIM21

1

20

Small-scale

0.724

High

1162722

FZR1
Fizzy-related protein homolog

5

8

Small-scale

0.723

High

507211

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.710

High

718575

CDC27
Cell division cycle protein 27 homolog

5

7

Small-scale

0.704

High

1162697

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

20

High-throughput

0.698

High

1086859

CDC20
Cell division cycle protein 20 homolog

4

14

Small-scale

0.694

High

272670

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

14

High-throughput

0.691

High

1162715

CDC23
Cell division cycle protein 23 homolog

3

7

Small-scale

0.664

High

1162721

FBX5
F-box only protein 5

1

0

Small-scale

0.656

High

48358

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

20

Small-scale

0.647

High

1028225

MDM2
E3 ubiquitin-protein ligase Mdm2

1

15

Small-scale

0.647

High

1153158

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

20

Small-scale

0.647

High

1162670

HECD3
E3 ubiquitin-protein ligase HECTD3

1

20

Small-scale

0.647

High

1162674

OTU7B
OTU domain-containing protein 7B

1

8

Small-scale

0.647

High

1162690

OTUB1
Ubiquitin thioesterase OTUB1

1

12

Small-scale

0.647

High

1162680

IFTAP
Intraflagellar transport-associated protein

3

0

High-throughput

0.638

High

764794

CTNB1
Catenin beta-1

2

3

Small-scale

0.624

High

144179

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

17

Small-scale

0.618

High

302540

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

Small-scale

0.618

High

325862

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.618

High

342894

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

Small-scale

0.618

High

773524

COPB2
Coatomer subunit beta'

1

1

Small-scale

0.618

High

890493

RBP2
E3 SUMO-protein ligase RanBP2

1

1

Small-scale

0.618

High

957085

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

16

Small-scale

0.618

High

970585

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

16

High-throughput

0.618

High

1147521

UBE3C
Ubiquitin-protein ligase E3C

1

20

Small-scale

0.618

High

1162671

UBR4
E3 ubiquitin-protein ligase UBR4

1

13

Small-scale

0.618

High

1162672

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

20

Small-scale

0.618

High

1162673

RN213
E3 ubiquitin-protein ligase RNF213

1

3

Small-scale

0.618

High

1162691

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.618

High

1162714

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.618

High

1162681

YAF2
YY1-associated factor 2

2

0

High-throughput

0.602

High

1162711

ZRAN1
Ubiquitin thioesterase ZRANB1

2

17

Small-scale

0.595

High

1162723

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

5

Small-scale

0.595

High

1162724

TNPO3
Transportin-3

1

1

High-throughput

0.590

High

1162701

LRC4C
Leucine-rich repeat-containing protein 4C

2

1

High-throughput

0.574

High

683466

IKBA
NF-kappa-B inhibitor alpha

1

13

Small-scale

0.561

High

728271

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

Small-scale

0.561

High

951700

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

0

Small-scale

0.559

High

484554

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

1162685

US6NL
USP6 N-terminal-like protein

1

2

High-throughput

0.536

High

1162693

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.536

High

1162704

ING3
Inhibitor of growth protein 3

1

1

High-throughput

0.536

High

1162682

CDK20
Cyclin-dependent kinase 20

1

4

High-throughput

0.515

High

984133

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.515

High

854437

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

High-throughput

0.513

High

1162684

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1162695

RUSC1
AP-4 complex accessory subunit RUSC1

1

0

High-throughput

0.513

High

1162710

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

288423

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

Small-scale

0.501

High

340637

STABP
STAM-binding protein

1

1

Small-scale

0.501

High

422194

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

853475

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

9

Small-scale

0.501

High

927009

ATX3
Ataxin-3

1

1

Small-scale

0.501

High

1092967

CDC16
Cell division cycle protein 16 homolog

1

7

Small-scale

0.501

High

1162686

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.501

High

1162716

APC7
Anaphase-promoting complex subunit 7

1

4

Small-scale

0.501

High

1162720

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

5

Small-scale

0.501

High

1162678

MILR1
Allergin-1

1

3

High-throughput

0.489

High

1162692

LRC3B
Leucine-rich repeat-containing protein 3B

1

2

High-throughput

0.489

High

583870

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.480

High

1162698

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.480

High

1162702

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.480

High

1162717

APC5
Anaphase-promoting complex subunit 5

1

0

Small-scale

0.480

High

1162718

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.480

High

214840

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

2

Small-scale

0.479

High

260025

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

319801

UFL1
E3 UFM1-protein ligase 1

1

6

Small-scale

0.479

High

363348

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

535118

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

537240

HSP7C
Heat shock cognate 71 kDa protein

1

3

Small-scale

0.479

High

558174

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

559372

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

588816

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

620391

NUCL
Nucleolin

1

3

Small-scale

0.479

High

695588

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

761416

HS71L
Heat shock 70 kDa protein 1-like

1

3

Small-scale

0.479

High

768313

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

842775

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

2

Small-scale

0.479

High

857333

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

3

Small-scale

0.479

High

879149

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

885789

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.479

High

898674

RL14
Large ribosomal subunit protein eL14

1

1

Small-scale

0.479

High

934683

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

960128

RL26
Large ribosomal subunit protein uL24

1

1

Small-scale

0.479

High

981842

RL23
Large ribosomal subunit protein uL14

1

1

Small-scale

0.479

High

1067401

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1099953

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

1106339

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

8

High-throughput

0.479

High

1150972

PCH2
Pachytene checkpoint protein 2 homolog

1

3

Small-scale

0.479

High

1162679

ZN598
E3 ubiquitin-protein ligase ZNF598

1

5

Small-scale

0.479

High

1162687

LPP
Lipoma-preferred partner

1

2

Small-scale

0.479

High

1162689

OPTN
Optineurin

1

5

High-throughput

0.479

High

1162694

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.479

High

1162696

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

6

Small-scale

0.479

High

1162703

SIAS
N-acetylneuraminate-9-phosphate synthase

1

1

Small-scale

0.479

High

1162712

SRP68
Signal recognition particle subunit SRP68

1

1

Small-scale

0.479

High

1162713

TBK1
Serine/threonine-protein kinase TBK1

1

7

Small-scale

0.479

High

487372

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

728951

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

Small-scale

0.458

High

975716

RL7A
Large ribosomal subunit protein eL8

1

0

Small-scale

0.458

High

984423

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.458

High

1054292

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

0

Small-scale

0.458

High

1143883

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.458

High

1162675

PMF1
Polyamine-modulated factor 1

1

0

Small-scale

0.458

High

1162677

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1162700

NCOA5
Nuclear receptor coactivator 5

1

0

Small-scale

0.458

High

1162706

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

Small-scale

0.458

High

1162707

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

Small-scale

0.458

High

1162669

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1162676

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1162699

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

563836

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

226327

SNG1
Synaptogyrin-1

1

0

High-throughput

0.279

Low

1162688

ELMO3
Engulfment and cell motility protein 3

1

0

High-throughput

0.279

Low

1063284

GOGA2
Golgin subfamily A member 2

1

0

Small-scale

0.249

Low

1162683

SVOPL
Putative transporter SVOPL

1

0

Small-scale

0.249

Low

1162708

DPM3
Dolichol-phosphate mannosyltransferase subunit 3

1

0

Small-scale

0.249

Low

303681

JTB
Protein JTB

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025