HitPredict

Interactor 1: CASP9 (P55211)
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]
Gene: CASP9

Interactor 2: BIRC8 (Q96P09)
Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis-like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis)
Gene: BIRC8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	25416956, 32296183, 11390657, 28514442, 33961781
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CARD~zf-C3HC4_3, BIR~Peptidase_C14
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Hs			1 236
+	Hs
		876987 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		Q6PIA0_HUMAN (1-236): 2.73e-86: 257: 99.15
+	Hs
		876997 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC7_HUMAN (1-236): 4.79e-61: 195: 33.47
+	Hs
		877004 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC6_HUMAN (1-185): 2.65e-36: 137: 20.31
+	Hs
		177664 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC5_HUMAN (4-100): 4.13e-27: 103: 27.89
+	Hs
		876995 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		RNF34_HUMAN (161-236): 2.91e-23: 98: 36.84
+	Mm
		140032 CASP9_MOUSE (1-416): 3.71e-164: 470: 71.81		BIRC3_MOUSE (4-95): 2.14e-17: 82.7: 32.98
+	Hs
		876980 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC3_HUMAN (4-158): 5.42e-18: 84.3: 24.20
+	Hs
		876981 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC2_HUMAN (4-148): 2.85e-16: 79.3: 24.49
+	Hs
		876972 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		876977 CASP9_HUMAN (1-416): 7.3e-163: 465: 100.00		BIRC1_HUMAN (1-72): 3.69e-13: 70.4: 32.43
+	Rn
		1337442 Q9JHK1_RAT (1-416): 8.46e-159: 457: 71.37		XIAP_RAT (3-211): 4.75e-14: 72.7: 16.90
+	Hs
		1059377 CASP8_HUMAN (10-415): 2.07e-109: 332: 26.19		BIRC6_HUMAN (1-185): 2.65e-36: 137: 20.31
+	Hs
		788252 CASP2_HUMAN (1-413): 2.57e-123: 366: 28.18		BIRC2_HUMAN (4-148): 2.85e-16: 79.3: 24.49
+	Hs
		667461 CASP1_HUMAN (10-413): 3.53e-121: 359: 23.45		BIRC3_HUMAN (4-158): 5.42e-18: 84.3: 24.20
+	Hs
		1059332 CASP8_HUMAN (10-415): 2.07e-109: 332: 26.19		RFFL_HUMAN (64-236): 4.82e-24: 100: 17.78
+	Hs
		1059336 CASP8_HUMAN (10-415): 2.07e-109: 332: 26.19		RNF34_HUMAN (161-236): 2.91e-23: 98: 36.84
+	Hs
		1035745 CASP8_HUMAN (10-415): 2.07e-109: 332: 26.19		BIRC3_HUMAN (4-158): 5.42e-18: 84.3: 24.20
+	Hs
		1036271 CASP8_HUMAN (10-415): 2.07e-109: 332: 26.19		BIRC2_HUMAN (4-148): 2.85e-16: 79.3: 24.49
+	Hs
		830276 CASP4_HUMAN (3-413): 4.56e-111: 332: 20.29		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07
+	Hs
		957707 CASP8_HUMAN (10-415): 2.07e-109: 332: 26.19		XIAP_HUMAN (3-211): 1.12e-13: 71.6: 15.07