HitPredict

Interactor 1: CDN2D (P55273)
Cyclin-dependent kinase 4 inhibitor D (p19-INK4d)
Gene: CDKN2D

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 1732
+	Hs
		149375 RAI14_HUMAN (5-142): 1.32e-35: 132: 25.18		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		681718 CDN2C_HUMAN (9-164): 2.7e-45: 147: 43.04		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		148496 CDN2A_HUMAN (8-130): 3.41e-23: 91.3: 49.19		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Rn
		1144333 CSKI1_RAT (66-165): 2.07e-29: 114: 32.67		AKT3_RAT (13-404): 7.21e-133: 424: 31.76
+	Hs
		63086 POTEM_HUMAN (78-165): 5.79e-18: 81.6: 27.17		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		149043 ANR35_HUMAN (1-96): 3.76e-17: 79.6: 22.68		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		681717 CDN2B_HUMAN (12-126): 1.73e-24: 94: 51.72		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		681716 CDN2A_HUMAN (8-130): 3.41e-23: 91.3: 49.19		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		1021472 ANK3_HUMAN (46-164): 1.56e-38: 140: 24.17		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		965172 ANK2_HUMAN (38-164): 6.58e-37: 136: 24.22		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Mm
		103596 ANK3_MOUSE (46-164): 3.35e-37: 136: 24.17		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Mm
		949370 ANK2_MOUSE (38-164): 6.58e-37: 136: 24.22		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Hs
		1356406 ANR50_HUMAN (55-164): 1.58e-25: 103: 29.73		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		1335966 TANC2_HUMAN (23-163): 2.12e-23: 97.5: 18.97		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		791011 CDN2C_HUMAN (9-164): 2.7e-45: 147: 43.04		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Mm
		949287 EHMT1_MOUSE (2-90): 1.13e-14: 72.3: 16.67		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Hs
		1335960 TANC2_HUMAN (23-163): 2.12e-23: 97.5: 18.97		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		790949 CDN2B_HUMAN (12-126): 1.73e-24: 94: 51.72		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Hs
		790888 CDN2A_HUMAN (8-130): 3.41e-23: 91.3: 49.19		LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23
+	Mm
		936588 ANS1B_MOUSE (1-121): 4e-17: 79.6: 20.97		ROCK2_MOUSE (275-1052): 2.96e-23: 110: 12.98