HitPredict - High confidence protein-protein interactions

Interactor 1: CD38 (P56528)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (I-19) (NIM-R5 antigen) (CD antigen CD38)
Gene: CD38

Interactor 2: CD38 (P56528)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (I-19) (NIM-R5 antigen) (CD antigen CD38)
Gene: CD38

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.59	1.00	0.770

Property	Details
Experiments	22863568
Identification Methods	molecular sieving, anti tag coimmunoprecipitation, cosedimentation in solution, x-ray crystallography, cross-linking study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Rib_hydrolayse~Rib_hydrolayse
Common GO terms	GO:0001666 - response to hypoxia GO:0003953 - NAD+ nucleosidase activity GO:0005886 - plasma membrane GO:0007204 - positive regulation of cytosolic calcium ion concentration GO:0007565 - female pregnancy and 29 others more... GO:0008284 - positive regulation of cell population proliferation GO:0009410 - response to xenobiotic stimulus GO:0009725 - response to hormone GO:0009986 - cell surface GO:0010977 - negative regulation of neuron projection development GO:0014824 - artery smooth muscle contraction GO:0016020 - membrane GO:0016323 - basolateral plasma membrane GO:0016740 - transferase activity GO:0016798 - hydrolase activity, acting on glycosyl bonds GO:0016849 - phosphorus-oxygen lyase activity GO:0030307 - positive regulation of cell growth GO:0030890 - positive regulation of B cell proliferation GO:0031965 - nuclear membrane GO:0032024 - positive regulation of insulin secretion GO:0032355 - response to estradiol GO:0032526 - response to retinoic acid GO:0032570 - response to progesterone GO:0033194 - response to hydroperoxide GO:0042100 - B cell proliferation GO:0043066 - negative regulation of apoptotic process GO:0045779 - negative regulation of bone resorption GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045907 - positive regulation of vasoconstriction GO:0050853 - B cell receptor signaling pathway GO:0060292 - long-term synaptic depression GO:0061809 - NAD+ nucleotidase, cyclic ADP-ribose generating GO:0070555 - response to interleukin-1
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	304
Mm

1	304

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Last updated: 15 Jul 2024