HitPredict

Interactor 1: CTBP2 (P56545)
C-terminal-binding protein 2 (CtBP2)
Gene: CTBP2

Interactor 2: MECOM (Q03112)
Histone-lysine N-methyltransferase MECOM (EC 2.1.1.367) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
Gene: MECOM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	30462309, 23858473
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 1230
+	Hs
		881300 CTBP2_HUMAN (1-445): 0: 604: 100.00		PRD16_HUMAN (1-1230): 0: 813: 44.40
+	Mm
		56925 CTBP1_MOUSE (20-445): 0: 515: 80.56		PRD16_MOUSE (1-1230): 0: 834: 44.07
+	Hs
		1032624 CTBP1_HUMAN (20-445): 0: 520: 80.99		PRD16_HUMAN (1-1230): 0: 813: 44.40
+	Hs
		974550 CTBP1_HUMAN (20-445): 0: 520: 80.99		MECOM_HUMAN (1-1230): 0: 666: 90.02
+	Hs
		197281 SERA_HUMAN (35-410): 8.39e-125: 374: 27.32		MECOM_HUMAN (1-1230): 0: 666: 90.02
+	Hs
		881179 CTBP2_HUMAN (1-445): 0: 604: 100.00		ZNF79_HUMAN (770-966): 5e-35: 142: 20.19
+	Dm
		220670 CTBP_DROME (10-367): 1.28e-140: 412: 72.35		Q9VJ55_DROME (265-345): 2.51e-09: 63.5: 37.81
+	Hs
		1343652 GRHPR_HUMAN (16-354): 2.96e-111: 332: 23.75		PRDM9_HUMAN (74-232): 1.56e-17: 90.5: 27.59