HitPredict

Interactor 1: SIK1 (P57059)
Serine/threonine-protein kinase SIK1 (EC 2.7.11.1) (Salt-inducible kinase 1) (SIK-1) (Serine/threonine-protein kinase SNF1-like kinase 1) (Serine/threonine-protein kinase SNF1LK)
Gene: SIK1

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32707033, 36806887
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 783 Hs			1 247
+	Hs
		883214 SIK1_HUMAN (1-783): 0: 724: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		883218 SIK1_HUMAN (1-783): 0: 724: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		683233 SIK1_HUMAN (1-783): 0: 724: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		883215 SIK1_HUMAN (1-783): 0: 724: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646758 SIK1_HUMAN (1-783): 0: 724: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683925 SIK1_HUMAN (1-783): 0: 724: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		910013 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		905098 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982480 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Xl
		223345 Q8QGV3_XENLA (11-719): 4.86e-156: 475: 29.40		O57468_XENLA (1-244): 4.25e-141: 397: 63.12
+	Hs
		909730 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		904766 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		683699 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927511 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647266 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		684316 SIK2_HUMAN (8-763): 2.54e-166: 506: 44.11		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		683485 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		927214 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647041 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		684157 MARK2_HUMAN (5-716): 1.29e-153: 469: 29.61		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16