HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12446564
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 416
+	Hs
		883495 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		129545 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Hs
		883500 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		883631 RIPK4_HUMAN (1-832): 0: 726: 100.00		TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86
+	Hs
		201787 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		1023653 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		201785 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		201839 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Mm
		886050 RIPK2_MOUSE (31-276): 4.75e-55: 201: 44.49		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		1021002 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1020645 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1377873 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		1038345 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		129516 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Hs
		201788 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		201823 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		TRAF4_HUMAN (27-136): 3.55e-09: 60.3: 17.86
+	Hs
		129559 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF5_HUMAN (14-261): 1.36e-16: 83.8: 13.91
+	Hs
		1024671 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77