HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	21931591
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 832 Hs			1 618
+	Hs
		1036348 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		883555 RIPK4_HUMAN (1-832): 0: 726: 100.00		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		883505 RIPK4_HUMAN (1-832): 0: 726: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		201791 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		1206048 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		1036078 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		883482 RIPK4_HUMAN (1-832): 0: 726: 100.00		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		1036381 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		1036265 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		957782 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		862070 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83
+	Hs
		862026 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56
+	Mm
		1193396 DAPK1_MOUSE (578-830): 6.86e-62: 229: 26.74		MIB1_MOUSE (231-616): 1.04e-52: 197: 15.83
+	Hs
		201790 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		1036246 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		1035698 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		201782 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		957806 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		957698 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		XIAP_HUMAN (17-173): 6.46e-31: 128: 29.38
+	Hs
		1038292 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		RFFL_HUMAN (567-618): 2.51e-17: 85.8: 42.31