Protein: NC2B
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)

Gene: NC2B, DR1
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q01658

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1031898

NC2A
Dr1-associated corepressor

16

20

Small-scale

0.985

High

1031960

DPOE3
DNA polymerase epsilon subunit 3

5

10

High-throughput

0.924

High

628754

TBP
TATA-box-binding protein

5

4

Small-scale

0.917

High

1031896

NFYC
Nuclear transcription factor Y subunit gamma

3

20

High-throughput

0.861

High

284823

TADA3
Transcriptional adapter 3

5

2

Small-scale

0.714

High

964858

WDR5
WD repeat-containing protein 5

4

2

Small-scale

0.694

High

1031939

SGF29
SAGA-associated factor 29

4

2

Small-scale

0.694

High

1031962

MBIP1
MAP3K12-binding inhibitory protein 1

4

2

Small-scale

0.694

High

283461

TAD2A
Transcriptional adapter 2-alpha

4

5

Small-scale

0.686

High

1031934

KAT2A
Histone acetyltransferase KAT2A

4

11

Small-scale

0.686

High

1031968

YETS2
YEATS domain-containing protein 2

3

5

Small-scale

0.674

High

1031903

Q32MN6
TBP protein

1

4

High-throughput

0.665

High

1031910

H3C
Histone H3.3C

1

2

High-throughput

0.665

High

1031935

KAT2B
Histone acetyltransferase KAT2B

3

9

Small-scale

0.656

High

883506

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.618

High

1031920

ZZZ3
ZZ-type zinc finger-containing protein 3

2

2

High-throughput

0.611

High

1031959

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.576

High

1031909

CE162
Centrosomal protein of 162 kDa

2

1

High-throughput

0.571

High

1031916

SRCAP
Helicase SRCAP

1

4

High-throughput

0.536

High

1031950

ARP6
Actin-related protein 6

1

1

High-throughput

0.536

High

1031954

CSR2B
Cysteine-rich protein 2-binding protein

1

4

High-throughput

0.536

High

371794

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.515

High

421944

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

856645

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.515

High

946016

VSX2
Visual system homeobox 2

1

4

High-throughput

0.515

High

1031894

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

High-throughput

0.515

High

1031907

PHF19
PHD finger protein 19

1

4

High-throughput

0.515

High

1031908

DCAF8
DDB1- and CUL4-associated factor 8

1

3

High-throughput

0.515

High

1031924

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

1

High-throughput

0.515

High

1031933

DPF1
Zinc finger protein neuro-d4

1

1

High-throughput

0.515

High

1031963

ZN581
Zinc finger protein 581

1

2

High-throughput

0.515

High

1031966

KLF15
Krueppel-like factor 15

1

4

High-throughput

0.515

High

487202

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

952756

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.513

High

1031922

MIER1
Mesoderm induction early response protein 1

1

0

High-throughput

0.513

High

1031969

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

1031901

NFIL3
Nuclear factor interleukin-3-regulated protein

1

3

Small-scale

0.501

High

188478

NVL
Nuclear valosin-containing protein-like

1

0

High-throughput

0.493

High

250557

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.493

High

282237

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.493

High

288393

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

High-throughput

0.493

High

517579

ZSC22
Zinc finger and SCAN domain-containing protein 22

1

0

High-throughput

0.493

High

621860

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.493

High

822617

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

877090

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.493

High

954677

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.493

High

977203

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.493

High

1031893

RED
Protein Red

1

0

High-throughput

0.493

High

1031897

LPIN1
Phosphatidate phosphatase LPIN1

1

0

High-throughput

0.493

High

1031904

ZN829
Zinc finger protein 829

1

0

High-throughput

0.493

High

1031914

ASCL4
Achaete-scute homolog 4

1

0

High-throughput

0.493

High

1031923

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.493

High

1031928

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.493

High

1031929

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.493

High

1031930

MAGC3
Melanoma-associated antigen C3

1

0

High-throughput

0.493

High

1031931

JADE3
Protein Jade-3

1

0

High-throughput

0.493

High

1031936

RNF34
E3 ubiquitin-protein ligase RNF34

1

0

High-throughput

0.493

High

1031942

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

1031943

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.493

High

1031945

RPP25
Ribonuclease P protein subunit p25

1

0

High-throughput

0.493

High

1031965

ZN219
Zinc finger protein 219

1

0

High-throughput

0.493

High

1031948

PAR6B
Partitioning defective 6 homolog beta

1

1

High-throughput

0.489

High

184702

ATX7
Ataxin-7

1

1

High-throughput

0.479

High

606646

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

979517

H4
Histone H4

1

2

High-throughput

0.479

High

1031900

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.479

High

1031912

EDC4
Enhancer of mRNA-decapping protein 4

1

2

High-throughput

0.479

High

1031918

TAD2B
Transcriptional adapter 2-beta

1

5

High-throughput

0.479

High

1031926

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

1031956

TAF9B
Transcription initiation factor TFIID subunit 9B

1

1

High-throughput

0.479

High

1031949

PBX4
Pre-B-cell leukemia transcription factor 4

1

3

High-throughput

0.470

High

1031958

HES4
Transcription factor HES-4

1

1

High-throughput

0.470

High

1031961

STRN4
Striatin-4

1

3

High-throughput

0.470

High

1031973

EMIL1
EMILIN-1

1

1

High-throughput

0.470

High

213901

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.458

High

283597

SUPT3
Transcription initiation protein SPT3 homolog

1

0

High-throughput

0.458

High

319142

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

459551

PROF1
Profilin-1

1

0

High-throughput

0.458

High

533919

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

610300

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

697078

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

1031892

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

1031925

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1031937

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

1031947

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1031970

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

765405

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

172713

XPO1
Exportin-1

1

0

Small-scale

0.391

High

1031919

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

732808

GLPK
Glycerol kinase

1

0

High-throughput

0.279

Low

1031895

MTMR2
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2

1

0

High-throughput

0.279

Low

1031913

CP087
UPF0547 protein C16orf87

1

0

High-throughput

0.279

Low

46780

A0A384ME25
Epididymis secretory sperm binding protein

1

0

High-throughput

0.268

Low

60680

A2RU56
LOC401296 protein

1

0

High-throughput

0.268

Low

221562

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.268

Low

339258

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.268

Low

568958

ANXA8
Annexin A8

1

0

High-throughput

0.268

Low

1031899

MLC1
Membrane protein MLC1

1

0

High-throughput

0.268

Low

1031902

FA98C
Protein FAM98C

1

0

High-throughput

0.268

Low

1031905

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

1031906

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

1031911

F117B
Protein FAM117B

1

0

High-throughput

0.268

Low

1031917

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.268

Low

1031921

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

1031927

SPT22
Spermatogenesis-associated protein 22

1

0

High-throughput

0.268

Low

1031932

LAR4B
La-related protein 4B

1

0

High-throughput

0.268

Low

1031938

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

1031940

GMPPA
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha

1

0

High-throughput

0.268

Low

1031941

CH048
Uncharacterized protein C8orf48

1

0

High-throughput

0.268

Low

1031944

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.268

Low

1031946

RUSC1
AP-4 complex accessory subunit RUSC1

1

0

High-throughput

0.268

Low

1031951

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

0

High-throughput

0.268

Low

1031952

Q9H669
cDNA: FLJ22558 fis, clone HSI01557

1

0

High-throughput

0.268

Low

1031953

AUNIP
Aurora kinase A- and ninein-interacting protein

1

0

High-throughput

0.268

Low

1031955

CN093
Uncharacterized protein C14orf93

1

0

High-throughput

0.268

Low

1031957

GGA2B
Putative golgin subfamily A member 2B

1

0

High-throughput

0.268

Low

1031964

SPMA2
Sperm microtubule associated protein 2

1

0

High-throughput

0.268

Low

1031971

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.268

Low

1031972

RAI2
Retinoic acid-induced protein 2

1

0

High-throughput

0.268

Low

1031967

DNM3L
DNA

1

0

Small-scale

0.261

Low

157255

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

629794

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

1028732

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.249

Low

1031915

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025